REACTIONS OF 2,3-DICHLOROMALEIC ANHYDRIDE(1): II REACTIONS WITH BINUCLEOPHILES (4+2CYCLOCONDENSATION) FOR SYNTHESIS OF COMPOUNDS WITH POTENTIAL ANTIMICROBIAL ACTIVITY | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 2, Volume 3, Issue 1, June 1994, Page 8-19 PDF (6.54 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1994.186595 | ||||
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Authors | ||||
Mohamed Al-Ashmawi 1; Werner Meise2; Abdel-Halim El-Sayed3; El-Sayed Lashine4; Mansour Abou-Kull5 | ||||
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
2Pharmazeutisches Institute der Universitaet Bonn, Kreuzbergweg 26, D-5300 Bonn 1, Germany | ||||
3Department of Microbiology, Faculty of Pharmacy, Zagazig University, Egypt | ||||
4Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
5Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt | ||||
Abstract | ||||
The reaction of 2,3-dichloromaleimides 1a-f with binucleophiles, viz, o-aminophenol (2a) and o-phenylenediamine (2b) is described. Products isolated were dependent on both pH and the used reaction solvents. Many of the novel, fused pyrroloquinoxalines and maleimides showed remarkable antimicrobial activities. | ||||
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