Acute Paraphenylenediamine (PPD) Toxic Effects upon the Kidney after Single Oral Dose: An Experimental Study
Dawood, A., Hilal, M., Mohammed, S., Elsayed, R., Mohamed, K., Elsayed, H. (2015). Acute Paraphenylenediamine (PPD) Toxic Effects upon the Kidney after Single Oral Dose: An Experimental Study. EKB Journal Management System, 24(1), 95-105. doi: 10.21608/ajfm.2015.18661
Abdel-wahab Dawood; Maha Hilal; Soheir Mohammed; Reda Elsayed; Khaled Mohamed; Hoda Elsayed. "Acute Paraphenylenediamine (PPD) Toxic Effects upon the Kidney after Single Oral Dose: An Experimental Study". EKB Journal Management System, 24, 1, 2015, 95-105. doi: 10.21608/ajfm.2015.18661
Dawood, A., Hilal, M., Mohammed, S., Elsayed, R., Mohamed, K., Elsayed, H. (2015). 'Acute Paraphenylenediamine (PPD) Toxic Effects upon the Kidney after Single Oral Dose: An Experimental Study', EKB Journal Management System, 24(1), pp. 95-105. doi: 10.21608/ajfm.2015.18661
Dawood, A., Hilal, M., Mohammed, S., Elsayed, R., Mohamed, K., Elsayed, H. Acute Paraphenylenediamine (PPD) Toxic Effects upon the Kidney after Single Oral Dose: An Experimental Study. EKB Journal Management System, 2015; 24(1): 95-105. doi: 10.21608/ajfm.2015.18661

Acute Paraphenylenediamine (PPD) Toxic Effects upon the Kidney after Single Oral Dose: An Experimental Study

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Article 10, Volume 24, Issue 1, January 2015, Page 95-105  XML PDF (1.31 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2015.18661
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Authors
Abdel-wahab Dawood1; Maha Hilal2; Soheir Mohammed2; Reda Elsayed2; Khaled Mohamed3; Hoda Elsayed4
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Assiut University
2Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Sohag University, Egypt
3Assiut Chemical Laboratory, Medico-Legal Department, Ministry of Justice, Egypt.
4Histology Department, Faculty of Medicine, Sohag University, Egypt.
Abstract
Paraphenylenediamine (PPD) is a synthetic compound used widely as a hair dye. Ingestion of PPD results in major systemic problems which depend mainly on the dose taken.
The current study was designed to investigate PPD toxic effects upon the kidney after single oral dose of PPD in three groups of adult male albino rats. Groups II, III, and IV which received (8, 16, 80 mg/kg toxic, sublethal and lethal dose of PPD respectively), 10 per each group. Another 10 animals were served as a control group (group I) received only distilled water. Blood was collected for evaluation of kidney functions and measurement of PPD and its metabolites levels by HPLC. The kidneys were preserved for histopathological examinations and measurement of the level of PPD and its metabolites by HPLC. The results proved that acute ingestion of PPD can induce disturbed kidney functions. PPD was detected in plasma and the kidney in group IV and in the kidney only in group II and group III, while the metabolites (MAPPD and DAPPD) were detected in all treated groups. The histopathological findings showed that PPD cause mild, moderate and severe tubular damage. In a conclusion, this study established the renal toxic effects of acute ingestion of paraphenylene-diamine. 
Keywords
Paraphenylenediamine (PPD); Renal toxicity; oral exposure HPLC
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