FORMATION OF A DEXTRAN / B-CYCLODEXTRIN POLYMER BY IMMOBILIZED LEUCONOSTOC MESENTEROIDES IN CALCIUM ALGINATE BEADS | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 8, Volume 3, Issue 1, June 1994, Page 62-71 PDF (5.55 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1994.186610 | ||||
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| Authors | ||||
Abdel-Halim El-Sayed  1; Robert Coughlin2
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| 1Department of Microbiology, Faculty of Pharmacy, Zagazig University, Egypt | ||||
| 2SymBiotech, Inc. and Department of Chemical Engineering, University of Connecticut, Storrs, CT, USA | ||||
| Abstract | ||||
| Dextran was produced using immobilized cells of L. mesenteroides ATCC 10830 (NRRL SB-512F) in 3% calcium aiginate beads in absence and presence of 1% (w/v) B-cyclodextrin (B-CD). Information about the molecular structure of the produced polymers was obtained using size exclusion chromatography and on-line low angle laser light scattering (SEC/LALLS) detection. Addition of B-CD to the dextran production medium led to a drastic change in the structure of the produced dextran. Branching of the produced polymer in presence of ß-CD was drastically increased and possibly produced a star-like polymer containing B-CD in the center with different dextranyl residues attached to its primary or secondary hydroxyl groups.resolution. | ||||
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