THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC
SALEM, H., EL-BALLAL, S., SEDDEK, A. (1992). THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC. EKB Journal Management System, 28.1(55), 158-173. doi: 10.21608/avmj.1992.186641
H.A. SALEM; S.S. EL-BALLAL; A.Sh. SEDDEK. "THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC". EKB Journal Management System, 28.1, 55, 1992, 158-173. doi: 10.21608/avmj.1992.186641
SALEM, H., EL-BALLAL, S., SEDDEK, A. (1992). 'THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC', EKB Journal Management System, 28.1(55), pp. 158-173. doi: 10.21608/avmj.1992.186641
SALEM, H., EL-BALLAL, S., SEDDEK, A. THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC. EKB Journal Management System, 1992; 28.1(55): 158-173. doi: 10.21608/avmj.1992.186641

THE EFFECT OF AD, E VITAMIN MIXTURE ON EXPERIMENTALLY INDUCED MEPHOSFOLAN SHORT TERM TOXICITY IN MIC

Assiut Veterinary Medical Journal
Article 14, Volume 28.1, Issue 55, October 1992, Page 158-173  XML PDF (6.24 MB)
Document Type: Research article
DOI: 10.21608/avmj.1992.186641
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Authors
H.A. SALEM; S.S. EL-BALLAL; A.Sh. SEDDEK
Abstract
In this study, sixty mice were used for induction of short term toxicity with organophosp < /strong>horus comp < /strong>ound 'mephosfolan". They received tenth of the LD so twice weekly for two months. Twenty mice were then treated with AD, E vitamin mixture for further one month. Samples for histopathological and hematological investigations were taken. Histopathological changes after two months toxicity with mep < /strong>hosfolan were mainly degenerative and vascular. They were prominent in the liver, kidney, testis, lung heart, and intestine. Hematological examination revealed a significant decrease in total erythrocytic count, total leukocytic count, hemoglobin concentration, and packed cell volume. A highly significant decrease in true choline estrase activity was observed. Treatmemt with AD, E vitamin mixture for one month resulted only in regeneration of the testis. The other organs as well as the hematological p < /strong>arameters did not resp < /strong>ond. Sp < /strong>ontaneous recpvery was observed in the true chroline estrase activiity without significant differences between vitamin mixture treated and non-treated groups. The significance of these results was discussed.
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