UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS
Salem, H., El-Maamli, M., El-Sadek, M., Aboul Kheir, A. (1994). UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS. EKB Journal Management System, 3(1), 115-122. doi: 10.21608/zjps.1994.186709
Hesham Salem; Magda El-Maamli; Mohamed El-Sadek; Afaf Aboul Kheir. "UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS". EKB Journal Management System, 3, 1, 1994, 115-122. doi: 10.21608/zjps.1994.186709
Salem, H., El-Maamli, M., El-Sadek, M., Aboul Kheir, A. (1994). 'UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS', EKB Journal Management System, 3(1), pp. 115-122. doi: 10.21608/zjps.1994.186709
Salem, H., El-Maamli, M., El-Sadek, M., Aboul Kheir, A. UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS. EKB Journal Management System, 1994; 3(1): 115-122. doi: 10.21608/zjps.1994.186709

UTILITY OF DERIVATIVE SPECTROPHOTOMETRY FOR THE DETERMINATION OF FLUOROURACIL IN COMBINATION WITH ITS ALKALI - INDUCED DEGRADATION PRODUCTS

Zagazig Journal of Pharmaceutical Sciences
Article 16, Volume 3, Issue 1, June 1994, Page 115-122  XML PDF (4.11 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186709
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Authors
Hesham Salem email 1; Magda El-Maamli1; Mohamed El-Sadek2; Afaf Aboul Kheir1
1Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt
Abstract
A simple, rapid and direct spectrophotometric method for the determination of fluorouracil in presence of its alkali-induced degradation products is presented. The method is based on measuring the absolute value of 1D and 2D of the absorption curve at the chosen wavelengths. The validity of the method was confirmed using laboratory prepared mixtures of the intact drug with its alkali-induced degradation products. The method has been also applied for the assay of some pharmaceutical preparations. Moreover, alkaline degradations has been studied and a derivative spectrophotometric method for quantitative determination of these degradations, even in presence of the intact molecule is presented.
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