OPTIMIZATION AND MECHANISTIC STUDIES OF FACILE DEBROMINATION OF VINYL BROMIDES WITH VICINAL SUBSTITUTED AMINO GROUP RESIDUES | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 18, Volume 3, Issue 1, June 1994, Page 131-135 PDF (2.69 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1994.186723 | ||||
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Authors | ||||
Osama Al-Sabbagh 1; Mohamed El-Bermawy2; Mohamed EI-Sadek 1; Mohamed Al-Ashmawi2 | ||||
1Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt | ||||
2Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
Abstract | ||||
Debromination of α- bromoketones can be conducted easily. However, debromination of vinyl bromides is extremely difficult and requires vigorous conditions. This study describes the optimum conditions for the facile debromination of vinyl bromides. A plausible mechanism for the easy debromination is proposed. Also, attempted application of ring contraction of 2-bromocyclohexanediones using Favorskii conditions was unsuccessful. | ||||
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