INTERACTION OF XYLAZINE WITH GALLAMINE OR TOLAZOLINE ON THE NEUROMUSCULAR JUNCTION OF ANAESTHETISED DOGS
EI-Ashmawy, I., Bayomi, A., Fayed, A. (1994). INTERACTION OF XYLAZINE WITH GALLAMINE OR TOLAZOLINE ON THE NEUROMUSCULAR JUNCTION OF ANAESTHETISED DOGS. EKB Journal Management System, 3(1), 136-143. doi: 10.21608/zjps.1994.186735
Ibrahim EI-Ashmawy; Ahmed Bayomi; Abd El-Hasseib Fayed. "INTERACTION OF XYLAZINE WITH GALLAMINE OR TOLAZOLINE ON THE NEUROMUSCULAR JUNCTION OF ANAESTHETISED DOGS". EKB Journal Management System, 3, 1, 1994, 136-143. doi: 10.21608/zjps.1994.186735
EI-Ashmawy, I., Bayomi, A., Fayed, A. (1994). 'INTERACTION OF XYLAZINE WITH GALLAMINE OR TOLAZOLINE ON THE NEUROMUSCULAR JUNCTION OF ANAESTHETISED DOGS', EKB Journal Management System, 3(1), pp. 136-143. doi: 10.21608/zjps.1994.186735
EI-Ashmawy, I., Bayomi, A., Fayed, A. INTERACTION OF XYLAZINE WITH GALLAMINE OR TOLAZOLINE ON THE NEUROMUSCULAR JUNCTION OF ANAESTHETISED DOGS. EKB Journal Management System, 1994; 3(1): 136-143. doi: 10.21608/zjps.1994.186735

INTERACTION OF XYLAZINE WITH GALLAMINE OR TOLAZOLINE ON THE NEUROMUSCULAR JUNCTION OF ANAESTHETISED DOGS

Zagazig Journal of Pharmaceutical Sciences
Article 19, Volume 3, Issue 1, June 1994, Page 136-143  XML PDF (4.11 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186735
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Authors
Ibrahim EI-Ashmawy email 1; Ahmed Bayomi2; Abd El-Hasseib Fayed3
1Departments of Pharmacology, Faculty of Veterinary Medicine, Alexandria University, Egypt
2Departments of Surgery ,Faculty of Veterinary Medicine, Alexandria University, Egypt
3Departments of Physiology, Faculty of Veterinary Medicine, Alexandria University, Egypt
Abstract
Xylazine was tested on the neuromuscular transmission in anaesthetised dogs. In addition, its interactions with gallamine and tolazoline on the upper lip muscles of anaesthetised dogs have been studied. Xylazine inhibited neuromuscular transmission. Furthermore, xylazine potentiated the neuromuscular blocking action of gallamine. Pretreatment with tolazoline, prevented the depressant effect of xylazine on the neuromuscular transmission. At the same time, xylazine significantly prolonged the duration of anaesthesia caused by thiopental sodium in dogs. It could be concluded that xylazine inhibited neuromuscular transmission centrally via its action of the -2 adrenoceptors and its effect was potentiated with gallamine and prevented with tolazoline.
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