STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS
Al-Ashmawi, M., El-Sadek, M., El-Bermawy, M., Kadry, A., Al-Sabbagh, O. (1994). STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS. EKB Journal Management System, 3(1), 144-150. doi: 10.21608/zjps.1994.186740
Mohamed Al-Ashmawi; Mohamed El-Sadek; Mohamed El-Bermawy; Ashraf Kadry; Osama Al-Sabbagh. "STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS". EKB Journal Management System, 3, 1, 1994, 144-150. doi: 10.21608/zjps.1994.186740
Al-Ashmawi, M., El-Sadek, M., El-Bermawy, M., Kadry, A., Al-Sabbagh, O. (1994). 'STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS', EKB Journal Management System, 3(1), pp. 144-150. doi: 10.21608/zjps.1994.186740
Al-Ashmawi, M., El-Sadek, M., El-Bermawy, M., Kadry, A., Al-Sabbagh, O. STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS. EKB Journal Management System, 1994; 3(1): 144-150. doi: 10.21608/zjps.1994.186740

STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Zagazig Journal of Pharmaceutical Sciences
Article 20, Volume 3, Issue 1, June 1994, Page 144-150  XML PDF (3.38 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1994.186740
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Authors
Mohamed Al-Ashmawi email 1; Mohamed El-Sadek2; Mohamed El-Bermawy1; Ashraf Kadry3; Osama Al-Sabbagh4
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
2Dept. of Medicinal Chemistry, Faculty of Pharmacy, University of Zagazig, Zagazig , Egypt
3Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University
4Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Egypt
Abstract
Although acridines and many tricylic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents, we report the design and synthesis of nonclassical acridine derivatives. Biological evaluation of these acridine analogues showed a consistent structure-activity relationship. Some of these acridines showed potent antimicrobial activity, compound 22 exhibited MIC of 7 ug / mL.
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