Synthesis and Antimicrobial Efficacy of Some Novel Heterocyclic Acetyl Istain Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 38, Volume 65, Issue 1, January 2022, Page 341-351 PDF (580.84 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.80431.3985 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mahmoud Abuzeid1; Hemat Mohamed Dardeer  2; Elghreep Elporaey3; Moustafa Fawzy2
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| 1Chemistry Department, Faculty of science, South Valley University, Qena, Egypt | ||||
| 2Depatement of Chemistry-Faculty of science -South Vally University | ||||
| 3Departement of Chemistry, Faculty of Science, South Valley University | ||||
| Abstract | ||||
| A series of novel heterocyclic compounds containing N-acetyl isatine moiety were synthesized. Herein, reaction of N-acetyl isatine with water in the presence of a catalytic amount of glacial acetic acid, via a ring opening route, yielded 2-(2-acetamidophenyl)-2-oxoaceticacid,which acts as an adjustable precursor with different heteroaryl amines such as aniline, 2-amino pyridine, 5-amino-1,3,4-thiadiazole-2-thiol,phenylhydrazeine, for the preparation of different schiff bases. Furthermore, acetamide derivatives were prepared via the ring opening path of N-acetyl isatin, by the interaction of it with 2-aminomethylpyridine, aniline, and hydrazine hydrate. All prepared samples were confirmed by their spectral data such as FTIR, 1H-NMR, 13C-NMR, Mass spectrometry, and elemental analysis. Furthermore, all the obtained compounds were evaluated as antibacterial agents and gave promising results. | ||||
| Keywords | ||||
| N-acetylisatin; Schiff bases; NMR; azomethine group; antimicrobial | ||||
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