Paraoxonase 1 Gene Polymorphism in Patients with Atopic Dermatitis
Mikhael, N., Mohammed, S., Mustafa, A., Elbadrawy, M. (2020). Paraoxonase 1 Gene Polymorphism in Patients with Atopic Dermatitis. EKB Journal Management System, 5(Issue 8 part (1) - (2)), 275-278. doi: 10.21608/bjas.2020.187224
N.W. Mikhael; S.A. Mohammed; A.I. Mustafa; M.I. Elbadrawy. "Paraoxonase 1 Gene Polymorphism in Patients with Atopic Dermatitis". EKB Journal Management System, 5, Issue 8 part (1) - (2), 2020, 275-278. doi: 10.21608/bjas.2020.187224
Mikhael, N., Mohammed, S., Mustafa, A., Elbadrawy, M. (2020). 'Paraoxonase 1 Gene Polymorphism in Patients with Atopic Dermatitis', EKB Journal Management System, 5(Issue 8 part (1) - (2)), pp. 275-278. doi: 10.21608/bjas.2020.187224
Mikhael, N., Mohammed, S., Mustafa, A., Elbadrawy, M. Paraoxonase 1 Gene Polymorphism in Patients with Atopic Dermatitis. EKB Journal Management System, 2020; 5(Issue 8 part (1) - (2)): 275-278. doi: 10.21608/bjas.2020.187224

Paraoxonase 1 Gene Polymorphism in Patients with Atopic Dermatitis

Benha Journal of Applied Sciences
Article 44, Volume 5, Issue 8 part (1) - (2), December 2020, Page 275-278  XML PDF (389.96 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2020.187224
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Authors
N.W. Mikhael1; S.A. Mohammed2; A.I. Mustafa1; M.I. Elbadrawy2
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Medical Biochemistry and Molecular Biology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Atopic dermatitis, commonly called atopic eczema were considered to be a one sort of persistent and backsliding provocative sicknesses of skin with high heterogeneity and heritability. The principle point of this examination was to research the relationship between Paroxonase 1 quality 192Q/R and 55L/M polymorphisms and atopic dermatitis. Subjects and techniques: This was an imminent case-control study included 100 patients experiencing atopic dermatitis (AD) (Group A). Notwithstanding 100 obviously solid people of coordinated age and sex as a benchmark (Group B). Discovery of single nucleotide polymorphism (SNP) for paroxonase 1 quality (192 Q/R and 55 L/M) was finished utilizing explicit preliminaries by a polymerase chain response - based limitation section length polymorphism (PCR-RFLP) test .Results: L allele demonstrated fundamentally higher recurrence in AD patients when contrasted with control gatherings; with danger to grow AD. While 192Q/R RR, RQ+RR genotypes, R allele; 55L/M MM, ML+MM genotypes, M allele had lower recurrence in AD patients when contrasted with control gatherings. End: The QL haplotype was altogether connected with danger of AD. Further examination utilizing the rules and all the more fittingly fueled investigations ought to incredibly improve the trust in the gauge of danger factors and an impact of a specific way to deal with treatment.
Keywords
Paraoxonase 1 Gene Polymorphism; Atopic Dermatitis
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