HIV-1 RT-Associated RNase H review | ||||
| Archives of Pharmaceutical Sciences Ain Shams University | ||||
| Article 3, Volume 2, Issue 1, January 2018, Page 22-30 PDF (626.18 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/aps.2018.18731 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Madonna M. A. Mitry  ; Nermin S. Abdou ; Rabah A. T. Serya
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| Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt | ||||
| Abstract | ||||
| HIV-RT is an essential enzyme for HIV replication it comprises two associated functions: RNA- and DNA-dependent DNA polymerase (RDDP & DDDP) and ribonuclease H (RNase H). The RNase H is function to cleave RNA strand in RNA/DNA hybrid intermediate in the reverse transcription process. Currently, successful inhibitors target the polymerase function of HIV-RT. RNase H evolves to be a promising target for anti-HIV drug research. This review describes the compounds reported as HIV-1 RNase H inhibitors. | ||||
| Keywords | ||||
| HIV-1; ribonuclease H; reverse transcriptase; tropolone; hydrazone | ||||
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