MODULATION OF THE SEVERITY OF REPERFUSION-INDUCED ARRHYTHMIAS BY DIGOXIN IN THE ISOLATED RAT HEART
Zakaria, M., Ghareib, S., El-Fayoumi, H. (1993). MODULATION OF THE SEVERITY OF REPERFUSION-INDUCED ARRHYTHMIAS BY DIGOXIN IN THE ISOLATED RAT HEART. EKB Journal Management System, 2(2), 19-28. doi: 10.21608/zjps.1993.187349
Mohamed Zakaria; Salah Ghareib; Hassan El-Fayoumi. "MODULATION OF THE SEVERITY OF REPERFUSION-INDUCED ARRHYTHMIAS BY DIGOXIN IN THE ISOLATED RAT HEART". EKB Journal Management System, 2, 2, 1993, 19-28. doi: 10.21608/zjps.1993.187349
Zakaria, M., Ghareib, S., El-Fayoumi, H. (1993). 'MODULATION OF THE SEVERITY OF REPERFUSION-INDUCED ARRHYTHMIAS BY DIGOXIN IN THE ISOLATED RAT HEART', EKB Journal Management System, 2(2), pp. 19-28. doi: 10.21608/zjps.1993.187349
Zakaria, M., Ghareib, S., El-Fayoumi, H. MODULATION OF THE SEVERITY OF REPERFUSION-INDUCED ARRHYTHMIAS BY DIGOXIN IN THE ISOLATED RAT HEART. EKB Journal Management System, 1993; 2(2): 19-28. doi: 10.21608/zjps.1993.187349

MODULATION OF THE SEVERITY OF REPERFUSION-INDUCED ARRHYTHMIAS BY DIGOXIN IN THE ISOLATED RAT HEART

Zagazig Journal of Pharmaceutical Sciences
Article 3, Volume 2, Issue 2, December 1993, Page 19-28  XML PDF (4.42 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1993.187349
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Authors
Mohamed Zakaria email 1; Salah Ghareib2; Hassan El-Fayoumi3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
2Department of Pharmacology, Faculty of Pharmacy, Zagazig University,Zagazig, Egypt
3Department of Pharmacology, Faculty of Pharmacy, Zagazig University , Egypt
Abstract
In the present investigation, the effects of different concentrations of digoxin (5x10-8 -5 x 10-6 M) on the number of premature ventricular contractions (PVCS), incidence, onset and duration of ventricular tachycardia (VT) and fibrillation (VF) have been studied on the isolated rat heart.
Digoxin (5 x 10-8 - 5 x 10-6 M) had no effect on the number of premature ventricular contractions, the incidence and the duration of ventricular tachycardia. Digoxin at the high concentration (5 x 10-6 M) has significantly reduced the onset of reperfusion induced ventricular tachycardia. It also increased the incidence and duration of reperfusion induced ventricular fibrillation.
The present investigation suggests that administration of high doses of digoxin may modulate the severity of arrhythmias resulting from reperfusion of ischaemic myocardium. This effect may be mediated through the effect of digoxin on the distribution of potassium and calcium ions.
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