PHARMACOLOGICAL EVALUATION OF TOLTRAZURIL WITH SPECIAL REFERENCE TO ITS ADVERSE EFFECTS | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 11, Volume 2, Issue 2, December 1993, Page 117-129 PDF (5.41 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1993.187359 | ||||
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Authors | ||||
Mostafa Abd El Aziz 1; Sabri Abdel-Motal2; Mohamed Khairy3; Ashour El-Gammal2; Gamal Shams4; Abdel-Alem Fouad2; Elene Mankarios2 | ||||
1Department. of pharmacology, Faculty of Veterinary Medicine, Zagazig University. | ||||
2Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt. | ||||
3Pharmacology Department, Faculty of Veterinary Medicine, Zagazig University, Egypt. | ||||
4Pharmacology Department, Faculty of Vet. Med., Zagazig University, Egypt | ||||
Abstract | ||||
Toltrazuril which is a novel anticoccidial agent elicit an inhibitory effect on the isolated smooth muscles of both intestine and oviduct of chicken. It was proved that its effect is due to an antihistamine-like effect. Toltrazuril exerted a negative inotropic effect on isolated chicken's heart with a decrease in coronary outflow. The drug induced hypotension with increased respiratory rate. Moreover, oral adminstration of toltrazuril produced a significant increase in serum GOT, glucose, creatinine and uric acid. The drug elicited a significant decrease in serum GPT, total protein and cholesterol levels. Histopathological findings were discussed. | ||||
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