SYNTHESIS OF CERTAIN SUBSTITUTED 7-CHLORO-4- QUINAZOLONES OF PHARMACEUTICAL INTEREST | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 15, Volume 2, Issue 2, December 1993, Page 158-168 PDF (4.49 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1993.187364 | ||||
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Authors | ||||
Mohamed Al-Ashmawi 1; Mohamed Shabaan2; Refaat Omar2 | ||||
1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt | ||||
2Department of Organic Chemistry, Faculty of Pharmacy, Cairo University | ||||
Abstract | ||||
The synthesis of some N-(7-chioro-3-phenyl-4 (3H)-quinazolinon-2-ylmercaptoacetyi) hydrazones is described. Reacting 7-chloro-3-phenyl-4-quinazolinone-2-thione with ethyl chloroacetate yielded two isomeric esters. Condensation of these esters with hydrazine hydrate under different reaction conditions afforded the expected hydrazides in addition to some sulphur free products. | ||||
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