The significance of Aldehyde dehydrogenase 1A1 expression in colorectal carcinoma | ||||
| Benha Medical Journal | ||||
| Article 160, Volume 39, Special issue (Academic), September and October 2022, Page 1-18 PDF (1.24 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2021.45812.1326 | ||||
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| Authors | ||||
Eman Mohamed Said1; Hanaa Mohamed Abostate  2; Nashwa Mohamed Emara3; Hala Adel Agina4
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| 1Pathology department, Faculty of medicine, Benha University, Benha, Egypt | ||||
| 2Pathology department, Faculty of Medicine, Benha University, Benha, Egypt | ||||
| 3pathology departement, Faculty of medicine, Benha univerisity, Benha, Egypt | ||||
| 4pathology department, faculty of medicine, benha university, benha | ||||
| Abstract | ||||
| Background: Colorectal carcinoma (CRC) is the third most common cancer in the world constituting about 10% of all cancers. ALDH1A1 has been used as a stem cell marker, and plays important functional roles in stem cells. Expression of ALDH1A1 by cancer stem cells (CSCs) has been demonstrated in multiple types of cancers. Aim: This work aimed to evaluate ALDH1A1 expression in colorectal adenocarcinoma and determine the relation between ALDH1A1 expression and different clinico-pathological variables. Material and method: This is a selected retrospective study included 50 different cases of colorectal adenocarcinoma. ALDH1A1 immunostaining was performed for all cases. Results: There was a highly significant statistical difference between ALDH1A1 expression in studied cases according to tumor site, lymph node metastasis and TNM stage (P value | ||||
| Keywords | ||||
| Colorectal adenocarcinoma; ALDH1A1; stem cell marker | ||||
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