Correlation between serum IL-23 and serum total IgE levels in allergic rhinitis patients | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 8, Volume 30, Issue 3, July 2021, Page 59-63 PDF (295.04 K) | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
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| Author | ||||
Aya M. EL-Aidy 
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| Medical Microbiology and Immunology Department, Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt | ||||
| Abstract | ||||
| Background: Allergic rhinitis (AR) is an immunoglobulin E (IgE) mediated inflammatory chronic disorder of the nasal mucosa caused by contact to allergens which affects a significant percentage of population. Th17 cells might be involved in the acute phase of the allergic reaction. Th17 cells are regulated by IL-23, which is a member of the IL-12 cytokine family. IL-23 was suggested to be a pivotal cytokine involved in the pathogenesis of AR and may become a novel target in the treatment of AR. Objective: Here we investigate the role of serum IL-23 and its correlation with serum total IgE level in AR. Methodology: This case control study included the investigation of 48subjects. Blood samples were collected for measuring serum IL-23 and total IgE levels by ELISA. Results: positive correlation was found between IL-23 and total IgE serum level in AR patients. Conclusion: Positive correlation was found between serum IL-23 and serum total IgE levels in allergic rhinitis patients. | ||||
| Keywords | ||||
| Allergic rhinitis; serum IL-23; serum total IgE | ||||
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