Histopathological and Biochemical Evaluation of the Pulmonary Toxicity of Cadmium Chloride and thiocarbamate | ||||
The Egyptian Journal of Hospital Medicine | ||||
Article 2, Volume 7, Issue 1, April 2002, Page 28-40 PDF (665.16 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhm.2002.18818 | ||||
View on SCiNiTO | ||||
Authors | ||||
Somaya Y.M Hamoudah1; Samia I. El Naggar2; Haleem H.H3 | ||||
1Department of Forensic Medicine and Toxicology, Faculty of Medicine (for Girls) Al AL Azhar University | ||||
2Department of Pathology, Cairo University | ||||
3Department of Biochemistry, Animal Health Research Institute Dokki | ||||
Abstract | ||||
The aim of the present work is to study the acute pulmonary toxicity of cadmium chloride (CdCl) and diethyldithiocarbamate (DDTC) each separately and in "# $ %& '(( ) "%& '**+(), - # . # $ /! .0 . cadmium content in the blood and lung were measured by atomic absorption spectrophotometer. It was found that the blood cadmium concentration significantly '12!),. . " However, with combined treatment the cadmium level in the lung showed significant '1 2 !) / 0 , # ! Histopathological examination of the lung showed inflammatory infiltrate of alveolar septa specially around blood vessels in DDTC treated animals. While that were exposed to CdCl and to combined (CdCl + DDTC) showed interstitial fibrosis and chronic inflammation. These changes were more severe and serious with combined exposure. Moreover the electr " 0" ! of combined exposure showed damage of type I pneumocytes, hyperplasia of type II pneumocytes with loss of microvilli. While the interstitial tissue revealed collagen bundle and chronic inflammatory cells. | ||||
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