Age-related changes in microsome-dependent conversion of T-T, thyroid function and cadmium toxicity in albino rat. | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 11, Volume 7, Issue 1, April 2002, Page 126-140 PDF (288.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2002.18845 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Sohair A. Moustafa | ||||
| Department of Zoology, Faculty of Science, Ismailia, Egypt | ||||
| Abstract | ||||
| The impact of age on microsomal function, manifested by its ability to convert thyroid hormone thyroxine (T ) to triiodothyronine (T&), was investigated using four age '& ( ) -months). The data show impaired microsomal function with advancing age represented by a significant decrease in serum levels of T& and T&/T ratio. There was a decline in the liver glutathione (GSH), total proteins and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma- glutamyl transpeptidase (*GT). There was an-age associated increase in liver content of the lipid peroxidation products, thiobarituric acid (TBA)-reactants and the serum total protein. ++ , - . '(+ - / ' + -old) +0- 1-) mg/kg CdCl 2their controls were injected with distilled water. A higher susceptibility of senile rats to cadmium toxicity was manifested as a significantly higher decrease in their serum T& level and T&/T ratio than adult compared to control. A reduction in the adaptive response of senile animals was manifested by a less increase in hepatic GSH in senile than adult as compared to control. The level of hepatic TBA-reactants was significantly higher in treated than in control group. The increase was more pronounced in the senile group. A marked hepatic cellular damage indicated by an increase in the serum levels of the AST and ALT was more pronounced in senile compared with adult rats. Treatment resulted in a decrease in the serum *GT and liver triglycerides (TG). The decrease in both parameters was more evident in senile as compared to adult group. | ||||
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