Effect of Moringa olefiera on neurotoxicity induced by sodium fluoride in rats | ||||
| Mansoura Veterinary Medical Journal | ||||
| Article 20, Volume 22, Issue 2, June 2021, Page 91-96 PDF (1.64 MB) | ||||
| Document Type: Original Articles | ||||
| DOI: 10.21608/mvmj.2021.188544 | ||||
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| Authors | ||||
| Abeer Shalan1; Shimaa El- Sayed2; Gehad El- Sayed; El-Said El-Said | ||||
| 1Directorate of Veterinary Medicine, Mansoura 35511, Egypt. | ||||
| 2Department of Biochemistry, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. | ||||
| Abstract | ||||
| Objective: This study was carried out to evaluate the detoxifying effects of aqueous extract of Moringa Oleifera on sodium fluoride-induced neurotoxicity in male Wister rats. Design: Randomized controlled study. Animals: Forty rats Procedures: Rats were allocated into four equal groups (10 each). Basically, each group received the same basal diet for 30 days. The first group was not received additional treatment (negative control). However, the second group received 20 mg/kg b.wt sodium fluoride daily (positive control), the third group received sodium fluoride at a dose of 20 mg/kg b.wt and Moringa Oleifera at 300 mg/kg daily, and the fourth group received sodium fluoride at a dose of 20 mg/kg b.wt and Moringa Oleifera 500 mg/kg daily using a stomach tube. Results: Dopamine and serotonin were significantly increased in Moringa Oleifera treated rats at 300 and 500 mg/kg in comparison with rats treated with sodium fluoride, but the higher dose of M. Oleifera achieved the best result (1.23±0.13 vs. 0.31±0.013) and (2.95±0.019 vs. 0.91±0.016) respectively. TAC, SOD, catalase were significantly increased in Moringa Oleifera treated rats at 300 and 500 mg/kg in comparison with rats treated with sodium fluoride, versed with MDA significantly decreased in Moringa Oleifera treated rats Also, to improve the anatomical structure of the disease in the brain reduces heavy bleeding and neurodegenerative changes, and maintains normal nerve cells, improves antioxidant ability as a whole. Conclusion and clinical relevance: Collectively, our results indicate that Moringa Oleifera watery extract has a detoxifying effect on NaF induced neurotoxicity via improving neurotransmitters andantioxidant activity. | ||||
| Keywords | ||||
| Sodium fluoride; Moringa Oleifera; rat; neurotoxicity | ||||
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