Partial Analysis Of Tlx 1 And Tlx 3 Genes In Adult And Children Patients Of Acute T-Cell Lymphblastic Leukemia | ||||
| Benha Journal of Applied Sciences | ||||
| Article 17, Volume 6, Issue 3, May and June 2021, Page 101-107 PDF (623.89 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2021.188702 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| S.S. Abdeen1; M.A. Ahmad2; M.N. seddek1 | ||||
| 1Immunology, Dept., Faculty of Science, Benha Univ., Benha, Egypt | ||||
| 2Haematology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
| Abstract | ||||
| The genes TLX 1 and TLX 3 as two genes of the Hox gene family have been selected in this review. Such genes have been shown to have a certain function in malignancies, including acute lymphoblastic T cell leukaemia (T-ALL). The principal phases of the research involved extraction of DNA as well as gene sequence of normal and ill cases. This thesis included partial examination of the above two genes in T-cell Both patients for adults and infants. Further analyses were performed using bioinformatic tools to establish the variation in the secondary structure of mRNA. The key knowledge was obtained that the proposed protein products had physicochemical properties in relation to the secondary structure of mRNA. Finally, the variation in samples compared with standard controls will influence the stability of these protein products. This knowledge will serve both as a disease detector and in connection to patients with a relapse. | ||||
| Keywords | ||||
| expression; genes; Egyptian; acute; lymphoplastic; leukemia; patients | ||||
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