Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo
Hussein, K., Sorour, N., Alhusseini, N., Abdou, A., Habashy, A. (2021). Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo. EKB Journal Management System, 6(3), 149-153. doi: 10.21608/bjas.2021.188825
K.M. Hussein; N.E. Sorour; N.F. Alhusseini; A.G. Abdou; A.y. Habashy. "Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo". EKB Journal Management System, 6, 3, 2021, 149-153. doi: 10.21608/bjas.2021.188825
Hussein, K., Sorour, N., Alhusseini, N., Abdou, A., Habashy, A. (2021). 'Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo', EKB Journal Management System, 6(3), pp. 149-153. doi: 10.21608/bjas.2021.188825
Hussein, K., Sorour, N., Alhusseini, N., Abdou, A., Habashy, A. Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo. EKB Journal Management System, 2021; 6(3): 149-153. doi: 10.21608/bjas.2021.188825

Role of Isocitrate Dehydrogenase 2, Microphthalmia-Associated Transcription Factor and Alpha Melanocyte Stimulating Hormone in Patients with Non-Segmental Generalized Vitiligo

Benha Journal of Applied Sciences
Article 24, Volume 6, Issue 3, May and June 2021, Page 149-153  XML PDF (699.52 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.188825
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Authors
K.M. Hussein1; N.E. Sorour1; N.F. Alhusseini2; A.G. Abdou3; A.y. Habashy1
1Dermatology and Andrology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Medical Biochemistry & Molecular Biology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
3Pathology, Dept., Faculty of Medicine, Menoufia Univ., Menoufia, Egypt
Abstract
Background: Vitiligo is a complicated, multifaceted condition of the skin. Abnormalities in the surrounding keratinocytes may lead to death of the melanocytes because growth factors are deprived. Ultraviolet band B (NB-UVB) is a successful treatment option particularly in generalised individuals. Objective: The purpose of this research was to assess in lesional skin of vitiligo patients the levels of microphthalmia-associated transcription factor (MITF), alpha melanocyte stimulating hormone and isocitrate dehydrogenase 2 (IDH2) and the influence of NBUVB treatment on them. Methods: 25 patients have been enrolled. They got NBUVB twice weekly for a total of 20 sessions on non-consecutive days. Each patient received skin biopsies from lesional skin before and after treatment. Results: 10% of patients had great clinical response after treatment; 10% showed fair response; 40% showed moderate reactions; 35% showed poor reactions; and 5% exhibited advancing illness. Conclusion: NB-UVB is an effective means of treating vitiligo, by upregulating α MSH, the master regulator of melanogenesis.
Keywords
Vitiligo; NB-UVB; α MSH; Melanogenesis
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