SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS
Ebeid, M., Lashine, S., Abou Taleb, N., Abdel-Aziz, L., Amer, M. (1993). SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS. EKB Journal Management System, 2(1), 62-72. doi: 10.21608/zjps.1993.188988
Mohamed Ebeid; Sayed Lashine; Nageh Abou Taleb; Lobna Abdel-Aziz; Magdy Amer. "SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS". EKB Journal Management System, 2, 1, 1993, 62-72. doi: 10.21608/zjps.1993.188988
Ebeid, M., Lashine, S., Abou Taleb, N., Abdel-Aziz, L., Amer, M. (1993). 'SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS', EKB Journal Management System, 2(1), pp. 62-72. doi: 10.21608/zjps.1993.188988
Ebeid, M., Lashine, S., Abou Taleb, N., Abdel-Aziz, L., Amer, M. SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS. EKB Journal Management System, 1993; 2(1): 62-72. doi: 10.21608/zjps.1993.188988

SYNTHESIS OF SOME 1,3,4- OXADIAZOLES FROM ETHYL IMIDAZO [4,5-B] PYRIDINYL PROPIONATE AS PONTENTIAL ANTIINFLAMMATORY AGENTS

Zagazig Journal of Pharmaceutical Sciences
Article 6, Volume 2, Issue 1, June 1993, Page 62-72  XML PDF (4.73 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1993.188988
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Authors
Mohamed Ebeid email 1; Sayed Lashine2; Nageh Abou Taleb3; Lobna Abdel-Aziz4; Magdy Amer5
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt
3FACULTY OF PHARMACY, CAIRO UNIVERSITY
4Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt
5Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt.
Abstract
Synthesis of 2- (6-bromo -2- imidazo  [4,5-b] pyridinyl) ethyl -5-( substituted) thío 1,3,4 Oxadiazole derivatives is described. The preparation of 1,3,4 - Oxadiazoles was achieved by cyclization of the corresponding acid hydrazide. Mannich reaction was applied on these new oxadiazoles giving the corresponding Mannich bases .Two of the prepared compounds were tested for their analgesic, antipyritic and antiinflammatory activities to show promising effects.
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