POTENTIATION OF THE HYPOTENSIVE EFFECT OF CAPTOPRIL BY THE H2 BLOCKER CIMETIDINE IN THE NORMOTENSIVE ANAESTHETIZED RATS
Ghareib, S., Zakaria, M., El-Fayomi, H. (1993). POTENTIATION OF THE HYPOTENSIVE EFFECT OF CAPTOPRIL BY THE H2 BLOCKER CIMETIDINE IN THE NORMOTENSIVE ANAESTHETIZED RATS. EKB Journal Management System, 2(1), 92-103. doi: 10.21608/zjps.1993.188991
Salah Ghareib; Mohamed Zakaria; Hassan El-Fayomi. "POTENTIATION OF THE HYPOTENSIVE EFFECT OF CAPTOPRIL BY THE H2 BLOCKER CIMETIDINE IN THE NORMOTENSIVE ANAESTHETIZED RATS". EKB Journal Management System, 2, 1, 1993, 92-103. doi: 10.21608/zjps.1993.188991
Ghareib, S., Zakaria, M., El-Fayomi, H. (1993). 'POTENTIATION OF THE HYPOTENSIVE EFFECT OF CAPTOPRIL BY THE H2 BLOCKER CIMETIDINE IN THE NORMOTENSIVE ANAESTHETIZED RATS', EKB Journal Management System, 2(1), pp. 92-103. doi: 10.21608/zjps.1993.188991
Ghareib, S., Zakaria, M., El-Fayomi, H. POTENTIATION OF THE HYPOTENSIVE EFFECT OF CAPTOPRIL BY THE H2 BLOCKER CIMETIDINE IN THE NORMOTENSIVE ANAESTHETIZED RATS. EKB Journal Management System, 1993; 2(1): 92-103. doi: 10.21608/zjps.1993.188991

POTENTIATION OF THE HYPOTENSIVE EFFECT OF CAPTOPRIL BY THE H2 BLOCKER CIMETIDINE IN THE NORMOTENSIVE ANAESTHETIZED RATS

Zagazig Journal of Pharmaceutical Sciences
Article 9, Volume 2, Issue 1, June 1993, Page 92-103  XML PDF (5.28 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1993.188991
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Authors
Salah Ghareib email 1; Mohamed Zakaria2; Hassan El-Fayomi3
1Department of Pharmacology, Faculty of Pharmacy, Zagazig University,Zagazig, Egypt
2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
3Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig and Cairo Universities - Egypt
Abstract
The effects of captopril (1 mg/kg), cimetidine (25 mg/kg), and their combination on the arterial blood pressure, heart rate, ECG and the calculated double product of anaesthetized normotensive rats were investigated. Results showed that captopril alone but not cimetidine significantly reduced the arterial blood pressure of rats. This effect lasted for 150 min. of administration. Captopril, cimetidine or their combination did not change the heart rate of rats. Administration of captopril in cimetidine-pretreated rats significantly reduced the arterial blood pressure and the calculated double product. Both the intensity and duration of the reduction in blood pressure were significantly greater than that induced by captopril alone, since the duration of this effect was extended for more than 180 min. after administration. This effect had two peaks, the first one came after 30 min. and the second one after 150 min. and the values of these reductions were 24% and 37%, respectively. Conclusively, cimetidine potentiates the hypotensive effect of captopril in anaesthetized rats. The mechanism of this positive interaction may be in part due to that cimetidine may increase the plasma levels of captopril through reduction of its rate of metabolism. This effect may result from the capability of cimetidine to inhibit cytochrome P450 enzymes which may be involved in type I biotransformation of captopril and consequently reduces its rate of degradation.
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