SYNTHESIS AND PRELIMINARY TESTING OF SOME ANTHRANILIC ACID DERIVATIVES AS ANTIINFLAMMATORY, ANALGESIC AND ANTIPYRETIC AGENTS | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 14, Volume 2, Issue 1, June 1993, Page 140-149 PDF (4.43 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1993.188998 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mansour Abou-Kull 1; Sayed Lashine2; Abdalla El-Shanawani3; Nageh Abou Taleb4; Magdy Amer5 | ||||
1Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt | ||||
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt | ||||
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. | ||||
4FACULTY OF PHARMACY, CAIRO UNIVERSITY | ||||
5Department of Pharmacology, Faculty of Veterinary Medicine, University of Mansoura, Egypt. | ||||
Abstract | ||||
A series of N - 3 - chloro -N- substituted phenyl -2- maleimidyl anthranilic acid and its methyl ester were prepared. The reaction of either IV or V with potassium thiocyanate afforded quinazolinone thione derivatives. four of the prepared new compounds were screened pharmacologically for their antiinflammatory, analgesic and antipyretic properties. | ||||
Statistics Article View: 49 PDF Download: 36 |
||||