SUBCHRONIC EFFECTS OF THE ORAL ADMINISTRATION OF THE LYOPHILIZED AQUEOUS EXTRACT OF CHROZOPHORA VERBASCIFOLIA IN RATS | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 16, Volume 2, Issue 1, June 1993, Page 161-169 PDF (4.35 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1993.189000 | ||||
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Authors | ||||
Fathalla Harraz 1; Mohamed Farah2; Sayed Abdel-Aziz2 | ||||
1Dept of Vet. Med., College of Agric. and Vet. Med., King Saud Univ., Qassim, Bureidah, Saudi Arabia | ||||
2Dept of Vet. Med., College of Agric. and Vet. Med., King Saud Univ., Qassim, Bureidah, Saudi Arabia | ||||
Abstract | ||||
Daily oral doses (400 mg/kg.b.wt.) of the lyophilized aqueous extract of C. verbascifolia were given to adult Wistar rats for a period of 4 weeks. The results revealed a significant decrease in cholesterol level (P<0.05) and inorganic phosphorus (P < 0.001), in addition to a marked increase (P < 0.001) in serum albumin and calcium. The haemogram showed a marked leucocytopenia, lymphocytopenia, decreased neutrophils, monocytes (P < 0.001) and basophils counts (P<0.05). Moreover, a significant increase (P<0.01) in MCH was also recorded. Changes in body and organ weights as well as histopathological findings were also discussed. | ||||
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