MECHANISMS OF TENSION DEVELOPMENT INDUCED BY MONENSIN IN GUINEA-PIG AORTA : EFFECTS OF VERAPAMIL, OUABAIN, PRAZOSIN AND GLIBENCLAMIDE
Mohamed, M., Ahmed, A., El-Maraghy, N., Nawrath, H., El-Gharabawy, A. (1993). MECHANISMS OF TENSION DEVELOPMENT INDUCED BY MONENSIN IN GUINEA-PIG AORTA : EFFECTS OF VERAPAMIL, OUABAIN, PRAZOSIN AND GLIBENCLAMIDE. EKB Journal Management System, 2(1), 170-181. doi: 10.21608/zjps.1993.189001
Mohamed Mohamed; Ahmed Ahmed; Nabila El-Maraghy; H Nawrath; Atef El-Gharabawy. "MECHANISMS OF TENSION DEVELOPMENT INDUCED BY MONENSIN IN GUINEA-PIG AORTA : EFFECTS OF VERAPAMIL, OUABAIN, PRAZOSIN AND GLIBENCLAMIDE". EKB Journal Management System, 2, 1, 1993, 170-181. doi: 10.21608/zjps.1993.189001
Mohamed, M., Ahmed, A., El-Maraghy, N., Nawrath, H., El-Gharabawy, A. (1993). 'MECHANISMS OF TENSION DEVELOPMENT INDUCED BY MONENSIN IN GUINEA-PIG AORTA : EFFECTS OF VERAPAMIL, OUABAIN, PRAZOSIN AND GLIBENCLAMIDE', EKB Journal Management System, 2(1), pp. 170-181. doi: 10.21608/zjps.1993.189001
Mohamed, M., Ahmed, A., El-Maraghy, N., Nawrath, H., El-Gharabawy, A. MECHANISMS OF TENSION DEVELOPMENT INDUCED BY MONENSIN IN GUINEA-PIG AORTA : EFFECTS OF VERAPAMIL, OUABAIN, PRAZOSIN AND GLIBENCLAMIDE. EKB Journal Management System, 1993; 2(1): 170-181. doi: 10.21608/zjps.1993.189001

MECHANISMS OF TENSION DEVELOPMENT INDUCED BY MONENSIN IN GUINEA-PIG AORTA : EFFECTS OF VERAPAMIL, OUABAIN, PRAZOSIN AND GLIBENCLAMIDE

Zagazig Journal of Pharmaceutical Sciences
Article 17, Volume 2, Issue 1, June 1993, Page 170-181  XML PDF (5.35 MB)
Document Type: Original Article
DOI: 10.21608/zjps.1993.189001
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Authors
Mohamed Mohamed email 1; Ahmed Ahmed1; Nabila El-Maraghy2; H Nawrath3; Atef El-Gharabawy4
1Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
2Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt
3Dept. of Pharmacology, Faculty of Medicine, University of Mainz, Germany
4Dept. of Pharmacology, Faculty of Pharmacy, Zagazig University, Egypt
Abstract
The influence of monensin (10 µmol/L) alone and in the presence of verapamil (3 µmol/L) or ouabain (1 mmol) and prazosin (1 µmol/L) or glibenclamide (10 µmol/L) were studied on the muscle tension of guinea pig aorta. Changes in tissue sodium, potassium and calcium ion contents of the aortic muscle produced by monensin in the presence of prazosin were evaluated. Monensin in normal Tyrode's solution containing prazosin caused an increase in the resting tension followed by a decrease and returned to normal values. Verapamil reduced the muscle tension induced by monensin. After ouabain, monensin induced sustained increase in the resting tension. Glibenclamide partially reversed the relaxant phase of monensin in presence of norepinephrine. The findings of the present study indicate that the contraction induced by monensin in guinea Pig aorta is due to the increased influx of calcium through voltage-dependent calcium Channels as well as through Na+ - Ca2+ exchange mechanisms. Monensin produced relaxation of guinea pig aorta in part through the increase in K+ permeability via opening of K+-ATP channels.
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