SYNTHESIS OF NEW CONDENSED PYRIMIDINES : III | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 18, Volume 2, Issue 1, June 1993, Page 182-194 PDF (5.15 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1993.189002 | ||||
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| Authors | ||||
Mohamed Ebeid  1; Sayed Lashine2; Nageh Abou Taleb3; Lobna Abdel-Aziz4
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| 1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt | ||||
| 2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt | ||||
| 3FACULTY OF PHARMACY, CAIRO UNIVERSITY | ||||
| 4Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt | ||||
| Abstract | ||||
| Acylation of the o-aminonitrile (enaminonitrile) derivatives of certain pyrimido- [1, 6-a] indole, with acid anhydrides or acid chlorides was achieved yielding a tetracylic structure, pyrimido- [4',5' : 4,5 ] pyrimido [1,6-a] indole. The chlorine atom in the chloroalkyl moiety was replaced by different amines or condensed with thiourea and the formed salts were hydrolyzed to give the mercapto alkyl compounds. Moreover, enaminonitriles were reacted with oxalyl chloride to afford the 3-chlorocarbonyl derivatives from which esters and amides were prepared. The 3-carboxylic acid derivtives were also prepared and subjected to decarboxylation. Some of the prepared compounds were tested for their pharmacological activties. | ||||
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