FLUOROMETRIC DETERMINATION OF ZIDOVUDINE IN SPIKED HUMAN PLASMA | ||||
| Zagazig Journal of Pharmaceutical Sciences | ||||
| Article 5, Volume 1, Issue 2, December 1992, Page 128-134 PDF (2.86 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zjps.1992.189014 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Mokhtar Mabrouk 
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| DEPARTMENT OF PHARMACEUTICAL CHEMISTRY, FACULTY OF PHARMACY, UNIVERSITY OF TANTA, EGYPT | ||||
| Abstract | ||||
| A highly sensitive fluorometric procedure for determination of zidovudine is described. The procedure depends on the interaction between zidovudine with 7-hydroxy-4-methylcoumarin where a fluorophore of high fluorogenic activity is produced exhibiting wavelengths of maximum excitation and emission of 340 and 450 nm, respectively. The procedure is used for the determination of zidovudine in human plasma in the range of 2-8 ug ml-1 in a rectilinear relationship .The mean percentage recoveries were 99. 193± S.D 1.928 in case of bulk drug while it was 99.832± S.D 1.809 in case of 7 concentrations in human plasma. | ||||
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