SYNTHESIS OF NEW CONDENSED PYRIMIDINES: I | ||||
Zagazig Journal of Pharmaceutical Sciences | ||||
Article 5, Volume 1, Issue 1, June 1992, Page 43-54 PDF (5.02 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zjps.1992.189019 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mohamed Ebeid 1; Sayed Lashine2; Abdalla El-Shanawani3; Mansour Abou-Kull4; N. Abou Taleb5 | ||||
1Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt | ||||
2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Zagazig University, Egypt | ||||
3Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt. | ||||
4Medicinal Chemistry Department, Faculty of Pharmacy, University of Zagazig, Zagazig, Egypt | ||||
5Pharmaceutical Chemistry Department, Faculty of Pharmacy, university of Cairo, Egypt . | ||||
Abstract | ||||
2-Dicyanomethylidinoindoline (I) obtained from lactime ether of oxindole and malononitrile, when added to various isocyanates or isothiocyanates afforded 2-alkye-3-imino-1-oxo or thioxo-1,2,3,4,4a,5-hexahydro-pyrimido1,6-alindole-4-carbonitrile. The corresponding enaminonitriles were obtained by reduction with sodium borohydride. Álkylation and hydrolysis of the prepared compounds are also described . | ||||
Statistics Article View: 57 PDF Download: 75 |
||||