THE INFLUENCES OF METHYL PREDNISOLONE ON PUBERTY AND ESTROUS CYCLE OF FEMALE ALBINO RATS | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 1, Volume 20.2, Issue 40, September 1988, Page 1-6 PDF (1.58 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.1988.189357 | ||||
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| Authors | ||||
| WAFAA F. ALI; NAHED EL-TOUKHY; A. ABOUL-ELA; F.A. SOLIMAN | ||||
| Abstract | ||||
| The present study showed that injection of 1.0 or 2.0 mg methyl prednisolone acetate (MPA) into immature female rats resulted in a significant decrease in their rate of growth, increased deaths and retardation of the onset of p < /strong>uberty. Injection of MPA into immature female rats resulted in a significant decrease in serum FSH and increase LH level without affecting their concentration in the pituitaries. Administration of MPA into est rous rats resulted in a significant increase of FSH concentration in the serum and pituitary. MPA injection increased serum LH level, with a pronounced decrease of its concentration in the pituitary. During diestrus, administration of MPA led to a pronounced decrease in serum FSH level accompanied with a rise of its concentration in the pituitaries. Pituitary LH contents decreased without influencing serum LH level. It seems that, Exces methyl prednisolone acetate have an adverse effect on gonadal function which is attributed to its catabolic nature, | ||||
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