Diagnostic value of MMP-1 in chronic liver diseases
El-bakry, M., Mansour, A., Abdelrahman, A., Emam, G., Behairy, O. (2021). Diagnostic value of MMP-1 in chronic liver diseases. EKB Journal Management System, 6(4), 11-16. doi: 10.21608/bjas.2021.189503
M.M. El-bakry; A.I. Mansour; A.M. Abdelrahman; G.M.E. Emam; O.G.A. Behairy. "Diagnostic value of MMP-1 in chronic liver diseases". EKB Journal Management System, 6, 4, 2021, 11-16. doi: 10.21608/bjas.2021.189503
El-bakry, M., Mansour, A., Abdelrahman, A., Emam, G., Behairy, O. (2021). 'Diagnostic value of MMP-1 in chronic liver diseases', EKB Journal Management System, 6(4), pp. 11-16. doi: 10.21608/bjas.2021.189503
El-bakry, M., Mansour, A., Abdelrahman, A., Emam, G., Behairy, O. Diagnostic value of MMP-1 in chronic liver diseases. EKB Journal Management System, 2021; 6(4): 11-16. doi: 10.21608/bjas.2021.189503

Diagnostic value of MMP-1 in chronic liver diseases

Benha Journal of Applied Sciences
Article 3, Volume 6, Issue 4, August 2021, Page 11-16  XML PDF (519.71 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.189503
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Authors
M.M. El-bakry1; A.I. Mansour2; A.M. Abdelrahman3; G.M.E. Emam1; O.G.A. Behairy1
1Pediatrics, Dept.,Faculty of Medicine,Benha Univ.,Benha, Egypt
2clinical pathology,Dept.,Faculty of Medicine,Benha Univ.,Benha, Egypt
3Clinical pathology,Dept.,Faculty of Medicine,Benha Univ.,Benha, Egypt
Abstract
Background: Chronic liver disorders in children constitute an increasing concern with major public health impacts, the MMP is degrading diverse extracellular matrix macromolecules and involves tissue reshaping and repair in physiological processes. The purpose of this research was to assess the diagnostic usefulness of MMP-1 in children with chronic liver disorders. Methods: 60 children undertook this research; Group I (hepatic group): 60 children with chronic liver disease, Group II (control group): 20 seemingly healthy youngsters, The entire history of taking, comprehensive clinical examination, abdominal US and laboratory testing like a complete blood count and liver function tests have been performed for all children (Alt, AST, Albumin, PT, PTT, INR, Total and direct bilirubin), Liver biopsy was conducted in all patients, with human enzyme-connected immunosorbent testing measuring Serum MMP-1 levels (ELISA). Results: the mean MMP-1 in hepatic group was 11.2±2.1 ng/ml and in control group 32.7±17.4 ng/ml. In the hepatic group controlled, p < 0.001, MMP-1 was statistically lower in order to measure the performance of MMP-1 in liver fibrosis (>F1), AUC was 0.872 (95 percent confidence interval: 0.709-0.487), p < 0.001. Sensitivity was 95% at a cutoff threshold < 11.3 ng/ml and specificity was 95%. ROC testing was conducted to evaluate MMP-1 performance in detecting severe liver fibrosis (>F3); AUC p < 0.001. The sensitivity was 90% at cutoff point < 4.5 ng/ml and the specificity was 80%. Conclusion: Fibrosis identification in children with chronic liver disorders might benefit from MMP-1.
Keywords
Matrix metalloproteinase; MMP-1; Liver; Fibrosis
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