Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates
Elsayed, A., Esmail, Y., Assar, E., Kora, M. (2021). Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates. EKB Journal Management System, 6(4), 169-175. doi: 10.21608/bjas.2021.189910
A.S. Elsayed; Y.M. Esmail; E.H. Assar; M.I. Kora. "Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates". EKB Journal Management System, 6, 4, 2021, 169-175. doi: 10.21608/bjas.2021.189910
Elsayed, A., Esmail, Y., Assar, E., Kora, M. (2021). 'Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates', EKB Journal Management System, 6(4), pp. 169-175. doi: 10.21608/bjas.2021.189910
Elsayed, A., Esmail, Y., Assar, E., Kora, M. Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates. EKB Journal Management System, 2021; 6(4): 169-175. doi: 10.21608/bjas.2021.189910

Relation between urine soluble trigerring receptor expressed on myeloid cells (sTERM-1 ) and blood culture for diagnosis of late onset sepsis in neonates

Benha Journal of Applied Sciences
Article 26, Volume 6, Issue 4, August 2021, Page 169-175  XML PDF (795.81 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.189910
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Authors
A.S. Elsayed1; Y.M. Esmail2; E.H. Assar1; M.I. Kora1
1Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Clinical pathology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Background: The sepsis gold standard is to identify the blood-growing agent. However, the production of a pathogen is not feasible for various reasons, even in the finest facilities. The purpose of this research was to identify the relationship between myeloid cell myeloid cell (STREM-1)-soluble trigger receptor and blood culture to diagnose late onset septicism. Methods: 100 cases from newborn intensive care units (NICU) divided into the following categories were included in this comparative case/check research. Group 1: 60 patients with positive blood culture sepsis included, Group 2: 40 patients with negative blood culture sepsis and Group 3: 100 patients with healthy neonate. All of the newborns included have been submitted to comprehensive history, clinical and laboratory tests of CBC, CRP and urine sTREM-1. Outcome: 60 (60%) instances of positive blood culture were 83,28 ± 6,17 pg/ml of the mean uTREM1, compared to 51,19 ± 19,47 pg/ml of the negative crop group and 78,22 ± 0,25 pg/ml of the checks, p <0,001. ROC curve was used to evaluate uTREM's diagnostic results for positive blood culture, uTREM1 was able to forecast positive AUC=0.999 (p < 0.001), CI (0.990-1). The sensitivity was 98.33 percent at a cut-off of > 72 pg/ml, the specificity was 95 percent, 96.7 percent and 97.4 percent. Conclusion: Our findings support the use of uTREM-1 in newborn sepsis as a potentially simple and reliable diagnostic while awaiting results and results in culture.
Keywords
sTERM-1; blood culture; sepsis; neonates
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