COMPARISON OF 18F-FDG-PET/CT VERSUS WB DW-MRI IN STAGING AND EVALUATION OF RESPONSE FOR LYMPHOMA PATIENTS | ||||
| ALEXMED ePosters | ||||
| Article 195, Volume 3, Issue 4, December 2021, Page 26-27 | ||||
| Document Type: Preliminary preprint short reports of original research | ||||
| DOI: 10.21608/alexpo.2021.86452.1233 | ||||
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| Authors | ||||
mwanajaa abdalla mwachui  1; Ahmed Gowily2
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| 1Alexandria university | ||||
| 2Alexandria Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria Egypt. | ||||
| Abstract | ||||
| The aim of the study is to assess the diagnostic value of Whole Body DWI in the staging and assessment of treatment response in lymphoma as a viable alternative in comparison to FDG PET/CT. a prospective study enrolled 20 lymphoma patients including aggressive and indolent subtypes D for staging or treatment response assessment. The lesions detected by MRI-DWI were evaluated with PET/CT as the reference standard. The impact of DWI and PET/CT on disease staging was analyzed according to Ann Arbor. The mean age at diagnosis was 58.44 (SD ± 5.16) years. 90% (18/20) had NHL. 6/20 patients were recruited for treatment response. The other 14 patients had 100% agreement in staging; 9were stage IV, 1 stage III, 1 stage II, and 3 were stage I disease. The agreement was moderate (κ = 0.57)for Total nodal sites and very good (κ = 0.84) for extranodal sites. Discordance in extranodal sites in 2 cases included: splenic infiltration at DWI on one and focal Bone Marrow infiltration at FDG PET/CT on the other. Individual sites showed a good agreement κ> 0.69 except for hilar region with a poor agreement (κ = 0.35) but this did not impact staging.DWI is a good alternative to FDG PET/CT and can be used in varied lymphomas and as an alternative for radiation-free imaging due to its good level of agreement to the standard reference. It showed a good evaluation especially of extranodal sites and also nodal sites except for hilar LNs where FDG PET/CT remains superior | ||||
| Keywords | ||||
| DWI - Diffusion-weighted imaging; Lymphoma; FDG PET/CT; Ann Arbor staging | ||||
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