MONITORING OF THE HYPOTENSIVE EFFECT OF HIBISCUS SABDARIFFA EXTRACT USING DIFFERENT EXTRACTION CONDITIONS
Mohamed, N., Ahmed, A., Shokry, P., AL Bayomi, S. (2021). MONITORING OF THE HYPOTENSIVE EFFECT OF HIBISCUS SABDARIFFA EXTRACT USING DIFFERENT EXTRACTION CONDITIONS. EKB Journal Management System, 1(1), 55-60. doi: 10.21608/sjpms.2021.190421
Nesma M Mohamed; Amany S Ahmed; Peter Alfy Shokry; Soad AL Bayomi. "MONITORING OF THE HYPOTENSIVE EFFECT OF HIBISCUS SABDARIFFA EXTRACT USING DIFFERENT EXTRACTION CONDITIONS". EKB Journal Management System, 1, 1, 2021, 55-60. doi: 10.21608/sjpms.2021.190421
Mohamed, N., Ahmed, A., Shokry, P., AL Bayomi, S. (2021). 'MONITORING OF THE HYPOTENSIVE EFFECT OF HIBISCUS SABDARIFFA EXTRACT USING DIFFERENT EXTRACTION CONDITIONS', EKB Journal Management System, 1(1), pp. 55-60. doi: 10.21608/sjpms.2021.190421
Mohamed, N., Ahmed, A., Shokry, P., AL Bayomi, S. MONITORING OF THE HYPOTENSIVE EFFECT OF HIBISCUS SABDARIFFA EXTRACT USING DIFFERENT EXTRACTION CONDITIONS. EKB Journal Management System, 2021; 1(1): 55-60. doi: 10.21608/sjpms.2021.190421

MONITORING OF THE HYPOTENSIVE EFFECT OF HIBISCUS SABDARIFFA EXTRACT USING DIFFERENT EXTRACTION CONDITIONS

Sphinx Journal of Pharmaceutical and Medical Sciences
Volume 1, Issue 1, April 2021, Page 55-60  XML PDF (1.25 MB)
Document Type: Original research articles
DOI: 10.21608/sjpms.2021.190421
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Authors
Nesma M Mohamed email 1; Amany S Ahmed2; Peter Alfy Shokry3, 4; Soad AL Bayomi1
1Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt
2(Head of department of Pharmacognosy, Faculty of Pharmacy,Sphinx University, New Assiut), (Faculty of Pharmacy, Assiut University, Assiut)
3Eva Pharma for Pharmaceuticals and Appliances.
4Clinical Pharmacist, Om El Atebaa Hospital, Giza, Egypt
Abstract
Hypertension management poses a challenge in developing countries, where poverty, illiteracy and poor nutrition combine to exacerbate the condition. The study was carried out to examine the active constituents of aqueous extract of Hibiscus sabbdariffa calyces’ using LC/MS, together with evaluation of its in-vivo hypotensive properties upon using two different techniques in extraction. The obtained LC/MS chromatograms revealed the presence of difference in the constitution of both extracts HSMac, extracted with maceration, and HSDec extracted with decoction. The oscillographic technique was employed on a live rabbit to evaluate the in-vivo antihypertensive properties of the extract. In the in-vivo studies, the HSMac extract moderately reduced the mean arterial blood pressure (mmHg) of an anaesthesized normotensive rabbit from a control value of 110 (when normal saline was administered) to 90 at does 1g/kg, while the HSDec extract didn’t shown any significance change on the mean arterial blood pressure. These findings corroborate the use of macerated H. sabdariffa calyces’ extract as an antihypertensive agent in ethno-medicine.
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