Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells
Mohamed, N., Zaghloul, M., Ghonemy, O., El-Shinawi, M., Ibrahim, S. (2018). Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells. EKB Journal Management System, 3(1), 119-123. doi: 10.21608/bjas.2018.191078
N.M. Mohamed; M.S. Zaghloul; O.I. Ghonemy; M. El-Shinawi; S.A. Ibrahim. "Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells". EKB Journal Management System, 3, 1, 2018, 119-123. doi: 10.21608/bjas.2018.191078
Mohamed, N., Zaghloul, M., Ghonemy, O., El-Shinawi, M., Ibrahim, S. (2018). 'Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells', EKB Journal Management System, 3(1), pp. 119-123. doi: 10.21608/bjas.2018.191078
Mohamed, N., Zaghloul, M., Ghonemy, O., El-Shinawi, M., Ibrahim, S. Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells. EKB Journal Management System, 2018; 3(1): 119-123. doi: 10.21608/bjas.2018.191078

Expression Pattern of Hyaluronan Synthase2 in Inflammatory Breast Cancer Cells

Benha Journal of Applied Sciences
Article 21, Volume 3, Issue 1, March 2018, Page 119-123  XML PDF (291.77 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2018.191078
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Authors
N.M. Mohamed1; M.S. Zaghloul1; O.I. Ghonemy1; M. El-Shinawi2; S.A. Ibrahim3
1Zoology Dept., Faculty of Science, Benha Univ., Benha, Egypt
2General Surgery Dept., Faculty of Medicine, Ain Shams Univ., Cairo, Egypt
3Zoology Dept, Faculty of Science, Cairo Univ., Giza, Egypt.
Abstract
Breast cancer (BC) Is the most widely recognized threatening malignant disease around the whole world. It Is the second most incessant reason for malignant tumor growth related to death among woman at different ages. Inflammatory Breast Cancer (IBC) Is the most lethal form of BC with low survival rate. Because of lacking molecular markers, identification of new unique markers for IBC Is warranted.  Hyaluronic acid synthases (HASs), particularly HAS2, have shown a critical role in the metastasis of non-inflammatory breast cancer (non-IBC). In this study, we assessed HAS2 mRNA expression by qPCR in the human triple negative non-IBC MDA-MB-231 and IBC SUM-149 cell lines. Our data demonstrated that HAS2 mRNA expression was significantly upregulated in IBC vs. non-IBC breast cancer cell lines. In conclusion, the high expression of HAS2 may represents a marker for IBC and could have a role in IBC pathogenesis.
Keywords
HAS2; Breast cancer; Inflammatory breast cancer
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