Lymphoid enhancer binding factor-1 (LEF1): as a prognostic factor in patients with Chronic lymphocytic leukemia | ||||
Zagazig University Medical Journal | ||||
Article 22, Volume 29, Issue 2, March 2023, Page 469-478 PDF (392.14 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2021.89473.2310 | ||||
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Authors | ||||
Abdullah Mohamad Abd el hameed ![]() | ||||
1Clinical pathology. Faculty of medicine. Zagazig university. El sharia governorate.eygpt | ||||
2Clinical Pathology-Faculty of Medicine Zagazig University-Egypt | ||||
3Department of clinical pathology , faculty of medicine , Zagazig University | ||||
4medical oncology-Faculty of Medicine Zagazig University-Egypt | ||||
Abstract | ||||
Abstract: Background: Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the world. CLL involves the abnormal activation of Wingless-type (Wnt) signaling pathway. Lymphoid enhancer-binding factor 1 (LEF1) is a member of the LEF1/T-cell factor (TCF) family of transcription factors Aim: To evaluate LEF1 expression in CLL and its impact on risk stratification and response to therapy. Subjects and methods: This study was conducted on 32 patients recently diagnosed as chronic lymphocytic leukemia . Complete blood picture, LDH , bone marrow aspiration , immunophenotyping , cytogenetic analysis and assessment of LEF1 expression by real time PCR were done for all patients. Results: The prognostic value for LEF1 was evaluated. There was a significant difference between Low LEF group and high LEF group as regards mortality (P .006), All the patients in low LEF group were alive at the end of follow up period, while in high LEF group five were alive at the end of follow up period and two died during the study. The overall survival of patient's low LEF level was longer than patients with high LEF level. Such difference was statistically significant (P=0.005). Conclusion: level of expression of LEF in CLL patients may be valuabale in predicting the survival | ||||
Keywords | ||||
CLL; LEF1; real-time PCR | ||||
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