Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives
Ewies, E., El-Sayed, N., El-Hussieny, M., Abdelaziz, M. (2021). Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives. EKB Journal Management System, 64(12), 7165-7173. doi: 10.21608/ejchem.2021.88648.4263
Ewies Ewies; Naglaa Fathy El-Sayed; Marwa El-Hussieny; Mohamed Abdelaziz. "Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives". EKB Journal Management System, 64, 12, 2021, 7165-7173. doi: 10.21608/ejchem.2021.88648.4263
Ewies, E., El-Sayed, N., El-Hussieny, M., Abdelaziz, M. (2021). 'Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives', EKB Journal Management System, 64(12), pp. 7165-7173. doi: 10.21608/ejchem.2021.88648.4263
Ewies, E., El-Sayed, N., El-Hussieny, M., Abdelaziz, M. Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives. EKB Journal Management System, 2021; 64(12): 7165-7173. doi: 10.21608/ejchem.2021.88648.4263

Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives

Egyptian Journal of Chemistry
Article 31, Volume 64, Issue 12, December 2021, Page 7165-7173  XML PDF (617.24 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.88648.4263
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Authors
Ewies Ewies email orcid 1; Naglaa Fathy El-Sayedorcid 2; Marwa El-Hussienyorcid 3; Mohamed Abdelazizorcid 4
1Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt
2Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, P.O. 12622, Giza, Egypt.
3Organometallic and Organometalloid Chemistry Department, Chemical Industries Division, NRC, Egypt.
4Microbial Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt
Abstract
5-Amino-2,3-dihydrophthalazine-1,4-dione (Luminol 1) reacted with some organophosphorus reagents such as phosphonium ylides, trialkyl phosphites, and tris(dialkylamino)phosphines to afford the corresponding olefinic products 5a-e, alkoxy-, and dialkylamino derivatives of Luminol 6a-e. 4-Thioxo-3,4-dihydrophthalazin-1(2H)-one derivative 7 was synthesized from the reaction of Luminol (1) with thiating Lawesson and Japanese reagents. Structures of the synthesized compounds were clarified based on their elemental and spectroscopic analyses. The synthesized compounds were evaluated for their antimicrobial activity against some bacterial and fungal strains.
Keywords
Luminol; Wittig; Trialkyl phosphite; Antimicrobial activity
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