Synthesis and Antimicrobial Evaluation of New 5-Amino-2,3-dihydrophthalazine-1,4-dione Derivatives | ||||
Egyptian Journal of Chemistry | ||||
Article 31, Volume 64, Issue 12, December 2021, Page 7165-7173 PDF (617.24 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2021.88648.4263 | ||||
View on SCiNiTO | ||||
Authors | ||||
Ewies Ewies 1; Naglaa Fathy El-Sayed 2; Marwa El-Hussieny 3; Mohamed Abdelaziz 4 | ||||
1Organometallic and Organometalloid Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt | ||||
2Organometallic and Organometalloid Chemistry, National Research Centre, Dokki, P.O. 12622, Giza, Egypt. | ||||
3Organometallic and Organometalloid Chemistry Department, Chemical Industries Division, NRC, Egypt. | ||||
4Microbial Chemistry Department, National Research Centre, 33 El-Bohouth St. (former El Tahrir St.), P.O. 12622, Dokki, Giza, Egypt | ||||
Abstract | ||||
5-Amino-2,3-dihydrophthalazine-1,4-dione (Luminol 1) reacted with some organophosphorus reagents such as phosphonium ylides, trialkyl phosphites, and tris(dialkylamino)phosphines to afford the corresponding olefinic products 5a-e, alkoxy-, and dialkylamino derivatives of Luminol 6a-e. 4-Thioxo-3,4-dihydrophthalazin-1(2H)-one derivative 7 was synthesized from the reaction of Luminol (1) with thiating Lawesson and Japanese reagents. Structures of the synthesized compounds were clarified based on their elemental and spectroscopic analyses. The synthesized compounds were evaluated for their antimicrobial activity against some bacterial and fungal strains. | ||||
Keywords | ||||
Luminol; Wittig; Trialkyl phosphite; Antimicrobial activity | ||||
Statistics Article View: 477 PDF Download: 623 |
||||