Serum MicroRNA-155 Expression Level as a Novel Biomarker in Alopecia Areata Patients
Sorour, N., Hamed, A., Tabl, H., Mousa, S. (2018). Serum MicroRNA-155 Expression Level as a Novel Biomarker in Alopecia Areata Patients. EKB Journal Management System, 3(2), 105-106. doi: 10.21608/bjas.2018.191356
N.E. Sorour; A.H. Hamed; H.A. Tabl; SH.G. Mousa. "Serum MicroRNA-155 Expression Level as a Novel Biomarker in Alopecia Areata Patients". EKB Journal Management System, 3, 2, 2018, 105-106. doi: 10.21608/bjas.2018.191356
Sorour, N., Hamed, A., Tabl, H., Mousa, S. (2018). 'Serum MicroRNA-155 Expression Level as a Novel Biomarker in Alopecia Areata Patients', EKB Journal Management System, 3(2), pp. 105-106. doi: 10.21608/bjas.2018.191356
Sorour, N., Hamed, A., Tabl, H., Mousa, S. Serum MicroRNA-155 Expression Level as a Novel Biomarker in Alopecia Areata Patients. EKB Journal Management System, 2018; 3(2): 105-106. doi: 10.21608/bjas.2018.191356

Serum MicroRNA-155 Expression Level as a Novel Biomarker in Alopecia Areata Patients

Benha Journal of Applied Sciences
Article 19, Volume 3, Issue 2, July 2018, Page 105-106  XML PDF (344.28 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2018.191356
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Authors
N.E. Sorour1; A.H. Hamed1; H.A. Tabl2; SH.G. Mousa2
1Dermatology, Venereology and Andrology Dept., Faculty of Medicine, Benha Univ, Benha, Egypt
2Medical Microbiology and Immunology Dept.,Faculty of Medicine, Benha Univ, Benha,Egypt
Abstract
MicroRNA-155 has been implicated in several autoimmune diseases, including experimental autoimmune encephalomyelitis and rheumatoid arthritis, due to its activity against a wide range of immunological gene targets. Overexpression of miR-155 may represent a hallmark feature in Alopecia areata (AA) disease pathogenesis and across multiple autoimmune conditions. It could potentially reflect and or influence the activation of T cells in autoimmune diseas. The present work aims is to assess serum level of miRNA-155 in patients with AA. MiR-155 level was identified by real-time polymerase chain reaction (PCR) in 30 patients with AA and 30 individuals as healthy controls. Results: There was a statistically significant increase in serum miR-155 level in patients than in controls. Conclusion: Serum level of miR-155 was significantly higher in patients with AA than controls, which indicated its role in the pathogenesis of AA.
Keywords
Alopecia Areata; polymerase chain reaction; MicroRNA
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