Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.
Badr El-Din, K., Ahmed, A., Khorshed, A., Derayea, S., Oraby, M. (2022). Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.. EKB Journal Management System, 65(2), 167-174. doi: 10.21608/ejchem.2021.82464.4098
Khaled Badr El-Din; Ahmed Ahmed; Ahmed Khorshed; Sayed Derayea; Mohamed Oraby. "Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.". EKB Journal Management System, 65, 2, 2022, 167-174. doi: 10.21608/ejchem.2021.82464.4098
Badr El-Din, K., Ahmed, A., Khorshed, A., Derayea, S., Oraby, M. (2022). 'Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.', EKB Journal Management System, 65(2), pp. 167-174. doi: 10.21608/ejchem.2021.82464.4098
Badr El-Din, K., Ahmed, A., Khorshed, A., Derayea, S., Oraby, M. Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.. EKB Journal Management System, 2022; 65(2): 167-174. doi: 10.21608/ejchem.2021.82464.4098

Smart Spectrophotometric Methods Based on Feasible Mathematical Processing and Classical Chemometry for The Simultaneous Assay of Alcaftadine and Ketorolac in Their Recently Approved Pharmaceutical Formulation.

Egyptian Journal of Chemistry
Article 19, Volume 65, Issue 2, February 2022, Page 167-174  XML PDF (605.09 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.82464.4098
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Authors
Khaled Badr El-Din1; Ahmed Ahmedorcid 2; Ahmed Khorshed3; Sayed Derayeaorcid 4; Mohamed Oraby email orcid 5
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt
2Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt
3b Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt.
4Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt
5Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt
Abstract
Alcaftadine (ALC) and Ketorolac tromethamine (KET) binary combination is a new co-formulated pharmaceutical product that is used to treat allergic conjunctivitis. The present work utilizes three simple, precise, accurate, and rapid spectrophotometric and chemometric methods to determine the recently released pharmaceutical formulation. The methods include the first derivative of absorbance spectrum (Method A), dual-wavelength (Method B), and absorbance subtraction methods (Method C). ICH guidelines have been used to validate the developed methods. Linear regression lines were found over the concentration range of 1-9 and 1-12 μg mL-1, 1-8 and 2-10 μg mL-1, and 2-10 and 2-10 μg mL-1 of ALC and KET for methods A, B, and C respectively. All the methods showed correlation coefficients higher than 0.999, in addition to low LOQ and LOD which indicate high sensitivity of the proposed methods.
Keywords
Alcaftadine; Ketorolac tromethamine; spectrophotometric; chemometric; pharmaceutical formulation
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