DIRECT AND TRANSPLACENTAL INDUCTION OF TUMOR IN RATS AFTER SINGIE EXPOSURE TO DIFLUBENZURON INSECTICIDE | ||||
| Assiut Veterinary Medical Journal | ||||
| Article 25, Volume 9, Issue 17.18, January 1982, Page 153-159 PDF (3.59 MB) | ||||
| Document Type: Research article | ||||
| DOI: 10.21608/avmj.1982.191565 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| F.E. SHAABAN; SOMMAYA, H.; EL. SAYED M.H.; KADRI, A. MOUSTAFA; A.H. ABU HADEED | ||||
| Dept. of Medicine, Faculty of Vet. Med., Zagazig University | ||||
| Abstract | ||||
| The oral LD50 of Diflubenzuron was determined in Agoza strain albino rats, survived animals were left and slaughtered after eleven months. Post mortem and histopatholo gical examination revealed the p < /strong>resence of squamous cell carcinoma in the stomach and polygonal cell carcinoma of the lungs. The offspring from mothers administered the LD50 dose at the 18th day of pregnancy developed hep < /strong>atocellular carcinoma which metastasis in their lungs. Detection, tissue distribution and evidence of transplac ental transmission of diflubenzuron were investigated by TLC, sp < /strong>ectrophotometric and Infra-red spectrscopic techniques. | ||||
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