Role of curcumin in ameliorating hazards caused by prenatal dexamethasone administration on development of the neonates suprarenal glands in albino rats ,( Light microscopic study).
Elsamman, W., Abd elnaeem, A., Ouies, S., Abd Ellah, M. (2021). Role of curcumin in ameliorating hazards caused by prenatal dexamethasone administration on development of the neonates suprarenal glands in albino rats ,( Light microscopic study).. EKB Journal Management System, 25(3), 15-20. doi: 10.21608/smj.2021.73425.1258
Walaa Nageh Elsamman; Abeer Fareed Abd elnaeem; Salwa M. Ouies; Mostafa Abd Elkhalik Abd Ellah. "Role of curcumin in ameliorating hazards caused by prenatal dexamethasone administration on development of the neonates suprarenal glands in albino rats ,( Light microscopic study).". EKB Journal Management System, 25, 3, 2021, 15-20. doi: 10.21608/smj.2021.73425.1258
Elsamman, W., Abd elnaeem, A., Ouies, S., Abd Ellah, M. (2021). 'Role of curcumin in ameliorating hazards caused by prenatal dexamethasone administration on development of the neonates suprarenal glands in albino rats ,( Light microscopic study).', EKB Journal Management System, 25(3), pp. 15-20. doi: 10.21608/smj.2021.73425.1258
Elsamman, W., Abd elnaeem, A., Ouies, S., Abd Ellah, M. Role of curcumin in ameliorating hazards caused by prenatal dexamethasone administration on development of the neonates suprarenal glands in albino rats ,( Light microscopic study).. EKB Journal Management System, 2021; 25(3): 15-20. doi: 10.21608/smj.2021.73425.1258

Role of curcumin in ameliorating hazards caused by prenatal dexamethasone administration on development of the neonates suprarenal glands in albino rats ,( Light microscopic study).

Sohag Medical Journal
Article 2, Volume 25, Issue 3, July 2021, Page 15-20  XML PDF (1.23 MB)
Document Type: Original Article
DOI: 10.21608/smj.2021.73425.1258
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Authors
Walaa Nageh Elsamman email 1; Abeer Fareed Abd elnaeem2; Salwa M. Ouies3; Mostafa Abd Elkhalik Abd Ellah4
1Anatomy department,faculty of medicine,sohag university
2Faculty of medecine Sohag University Anatomy department
3Anatomy department,sohag university,sohag,sohag
4Obstetrics and gynacology department Faculty of medicine Sohag University
Abstract
AAbstract: Introduction: The dexamethasone (Dx) is a synthetic glucocorticoid that pass through placental barrier especially in late gestation and affects the growth and maturation of most of fetal tissues so that The Dx is commonly used drug in preterm delivery to promote fetal lung growing, lowering the postnatal deaths from respiratory distress diseases.
Aim of work: This study was carried out to study the effects of dexamethasone on the development of neonates suprarenal gland and possible protective effect of curcumin against this.
Material & Methods: In this study a total of 12 adult pregnant female albino rats were included. The animals were subdivided into 3 groups, five rats for each group. the offspring were scarified at birth. The suprarenal glands were processed for light microscope studies .
Results: Variable pathological changes were observed in adrenal cortex of the dexamethasone treated group compared to the control one and these changes become little or not present on the curcumin and dexamethasone treated group.
conclusion: prenatal dexamethasone administration has enormous destructive effects on both the structure and fine structure of the developing adrenal gland. Therefore, it is highly recommended that its use must be restricted to the urgent necessity and in such case, curcumin as a potent antioxidant, can be utilized to ameliorate these adverse effects.
Keywords: development, adrenal gland, Dexamethasone, curcumin.
Keywords
Keywords: development; adrenal gland; Dexamethasone; curcumin
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