Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study
Zaki, M., El-Bassyouni, H., Hussein, M., Tawfeek, H., Girgiss, M., Ashour, M., Youness, E. (2022). Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study. EKB Journal Management System, 65(2), 175-179. doi: 10.21608/ejchem.2021.83757.4108
Moushira Zaki; Hala El-Bassyouni; Mona Abd Elmotaleb A. Hussein; Hend M. Tawfeek; Mina Wassef Girgiss; Magdi Ashour; Eman Youness. "Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study". EKB Journal Management System, 65, 2, 2022, 175-179. doi: 10.21608/ejchem.2021.83757.4108
Zaki, M., El-Bassyouni, H., Hussein, M., Tawfeek, H., Girgiss, M., Ashour, M., Youness, E. (2022). 'Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study', EKB Journal Management System, 65(2), pp. 175-179. doi: 10.21608/ejchem.2021.83757.4108
Zaki, M., El-Bassyouni, H., Hussein, M., Tawfeek, H., Girgiss, M., Ashour, M., Youness, E. Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study. EKB Journal Management System, 2022; 65(2): 175-179. doi: 10.21608/ejchem.2021.83757.4108

Brain-Derived Neurotrophic Factor (BDNF) Levels In Relation To Depression In Egyptian Diabetic Women: A Pilot Study

Egyptian Journal of Chemistry
Article 20, Volume 65, Issue 2, February 2022, Page 175-179  XML PDF (330.06 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.83757.4108
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Authors
Moushira Zakiorcid 1; Hala El-Bassyouniorcid 2; Mona Abd Elmotaleb A. Hussein3; Hend M. Tawfeek4; Mina Wassef Girgissorcid 5; Magdi Ashour6; Eman Youness email orcid 7
1biological anthropology department, National Research Centre, Giza, Egypt.
2Clinical Genetics Department, National Research Centre, Cairo, Egypt.
3Internal Medicine National Institute of Diabetes and Endocrinology, Cairo, Egypt.
4Internal Medicine Faculty of Medicine, Al-Azhar University- Girls.
5Medical Department, Medical Research Division, National Research Centre, Giza, Egypt.
6Medical Biochemistry Department, Medical Research Division, National Research Centre, Giza, Egypt
7Department of medical biochemistry National Research Centre, Giza, Egypt.
Abstract
Background: Brain-derived neurotrophic factor (BDNF) is a crucial moderator of neuronal plasticity in adults, a potential association between BDNF and depression has been reported. Besides BDNF plays a role in glucose and energy metabolism. Methods: This work included 180 women (25-55 years old). Ninety diabetic patients with the clinical diagnosis of depression and 90 were normal controls. Plasma BDNF was evaluated using ELISA. The Zung Self‑Rating Depression Scale (SDS) consisting of 20 objects with a Likert‑type scale after each was used. HbA1c were measured in each patient using a clinical auto-analyzer. Results: BDNF levels in serum decreased significantly in diabetic depressed women compared to controls. Moreover, BDNF levels were inversely proportional to age, BMI, HbAc1 and LDL.Conclusion: The study suggests that age, BMI, HbAc1 have a definite impact on the circulating levels of BDNF in peripheral blood. The outcomes delineate that BDNF could participate in glucose impairment and lipid metabolism in diabetic patients.
Keywords
Brain-Derived Neurotrophic Factor (BDNF); BMI; Depression; HbAc1; lipid profile; type 2 diabetes mellitus
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