Prospective Study on the Dose Distribution to the Middle-ear Structures during 3D Conformal Radiotherapy for Head and Neck Tumors and Dose Effect on Middle-ear Toxicity: Zagazig University Hospitals Experience.
Monged, R., Alhosainy, A., Alattar, A., Balata, S. (2022). Prospective Study on the Dose Distribution to the Middle-ear Structures during 3D Conformal Radiotherapy for Head and Neck Tumors and Dose Effect on Middle-ear Toxicity: Zagazig University Hospitals Experience.. EKB Journal Management System, 28(5), 1118-1125. doi: 10.21608/zumj.2021.91112.2319
Randa Monged; Ahmad Alhosainy; Ahmad Alattar; Safa Balata. "Prospective Study on the Dose Distribution to the Middle-ear Structures during 3D Conformal Radiotherapy for Head and Neck Tumors and Dose Effect on Middle-ear Toxicity: Zagazig University Hospitals Experience.". EKB Journal Management System, 28, 5, 2022, 1118-1125. doi: 10.21608/zumj.2021.91112.2319
Monged, R., Alhosainy, A., Alattar, A., Balata, S. (2022). 'Prospective Study on the Dose Distribution to the Middle-ear Structures during 3D Conformal Radiotherapy for Head and Neck Tumors and Dose Effect on Middle-ear Toxicity: Zagazig University Hospitals Experience.', EKB Journal Management System, 28(5), pp. 1118-1125. doi: 10.21608/zumj.2021.91112.2319
Monged, R., Alhosainy, A., Alattar, A., Balata, S. Prospective Study on the Dose Distribution to the Middle-ear Structures during 3D Conformal Radiotherapy for Head and Neck Tumors and Dose Effect on Middle-ear Toxicity: Zagazig University Hospitals Experience.. EKB Journal Management System, 2022; 28(5): 1118-1125. doi: 10.21608/zumj.2021.91112.2319

Prospective Study on the Dose Distribution to the Middle-ear Structures during 3D Conformal Radiotherapy for Head and Neck Tumors and Dose Effect on Middle-ear Toxicity: Zagazig University Hospitals Experience.

Zagazig University Medical Journal
Article 28, Volume 28, Issue 5, September 2022, Page 1118-1125  XML PDF (593.12 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.91112.2319
View on SCiNiTO View on SCiNiTO
Authors
Randa Monged email ; Ahmad Alhosainy; Ahmad Alattar; Safa Balata
Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: Head and neck cancer (HNC) is a significant public health problem over the world. Head and neck squamous cell carcinomas are the sixth most common malignancy worldwide. Radiation therapy (RT) is a corner stone in the treatment of HNC. Aim and objectives: The aim of this study was to analyze the dose distribution in the middle ear structures in patients with HNC after RT and to evaluate the dose effect on the occurrence of middle ear toxicity. Patients and methods: This prospective study was carried out in Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals. It included 24 patients with HNC treated with RT and dose distribution to the middle ear was calculated using dose volume histogram parameters to detect the correlation between the dose and the toxicity. Results: Patients with HNC treated with RT are associated with an incidence of middle ear toxicity in the form of otitis media with effusion and eustachian tube dysfunction depending on the mean dose to middle ear and ET D30. The toxicity is associated with middle ear mean dose ≥40Gy and ET D30 >52.75Gy. Head and neck tumors above the larynx are associated with a higher mean dose to middle ear than tumors of larynx and hypopharynx. Conclusion: RT in cases of HNC is associated with middle ear toxicity and the incidence of the toxicity depends on the dose of radiation to middle ear. And the dose depends on the site of the tumor.
Keywords
Head and Neck cancers; radiotherapy; middle ear dosimetry; otitis media with effusion; eustachian tube dysfunction
Statistics
Article View: 165
PDF Download: 96