Role of active vitamin D in protection against glucocorticoids induced metabolic syndrome and gastric lesion
Mohammed, M., Khowailed, A., Rashed, L., Rateb, E., Naeem, A. (2023). Role of active vitamin D in protection against glucocorticoids induced metabolic syndrome and gastric lesion. EKB Journal Management System, 29(3), 905-913. doi: 10.21608/zumj.2021.78141.2244
Marwa Mohammed; Akef Khowailed; Laila Rashed; Enas Rateb; Ahmed Naeem. "Role of active vitamin D in protection against glucocorticoids induced metabolic syndrome and gastric lesion". EKB Journal Management System, 29, 3, 2023, 905-913. doi: 10.21608/zumj.2021.78141.2244
Mohammed, M., Khowailed, A., Rashed, L., Rateb, E., Naeem, A. (2023). 'Role of active vitamin D in protection against glucocorticoids induced metabolic syndrome and gastric lesion', EKB Journal Management System, 29(3), pp. 905-913. doi: 10.21608/zumj.2021.78141.2244
Mohammed, M., Khowailed, A., Rashed, L., Rateb, E., Naeem, A. Role of active vitamin D in protection against glucocorticoids induced metabolic syndrome and gastric lesion. EKB Journal Management System, 2023; 29(3): 905-913. doi: 10.21608/zumj.2021.78141.2244

Role of active vitamin D in protection against glucocorticoids induced metabolic syndrome and gastric lesion

Zagazig University Medical Journal
Article 21, Volume 29, Issue 3, May and June 2023, Pages 905-913    PDF (1010.29 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.78141.2244
Authors
Marwa Mohammed* 1; Akef Khowailed2; Laila Rashed3; Enas Rateb1; Ahmed Naeem4
1Department of Physiology, Faculty of Medicine, Beni-Suef University
2Department of Physiology, Faculty of Medicine, Cairo University
3Department of Medical Biochemistry, Faculty of Medicine, Cairo University
4Department of pathology, Faculty of Medicine, Cairo University
Abstract
Background: Glucocorticoids are used in the treatment of several diseases, but they have many side effects. many actions for vitamin D have been discovered due to its strong antioxidant properties. Objective: The aim of the present study was to detect the protective effect of vitamin D against glucocorticoids induced metabolic syndrome and gastric lesion. Materials and methods: 24 adult male wistar albino rats were included. Rats were randomly allocated into 4 groups (6 rats/each group), group1 (control), group 2 (vitamin D treated ), group 3 (Dexamethasone treated ) and group 4 (dexamethasone with vitamin D treated ). Drugs were given intraperitoneally daily for 14 days. Blood pressure (BP) was measured before and after the experiment. Serum glucose, insulin, Lipid profile were measured. Also, angiotensin receptor 1 (AT1) gene expression in aortic tissue was detected. Histopathological Analysis for stomach was performed. Results: Dexamethasone resulted in a significant increase of BP, glucose, insulin and dyslipidemia with an increase of AT1 gene expression and a significant hypocalcemia was detected besides gastric lesions. Giving vitamin D with dexamethasone reversed these results. Conclusion: Vitamin D prevented dexamethasone induced metabolic syndrome and gastric lesion due to its antioxidant properties besides inhibition of AT1 gene expression.
Keywords
Dexamethaone; vitamin D; oxidative stress; AT1 gene expression
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