Prevalence and Risk Factors of Hepatitis C Virus Infection Among High-risk Egyptian Children | ||||
| International Journal of Medical Arts | ||||
| Article 5, Volume 3, Issue 4, October 2021, Page 1792-1796 PDF (1.16 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2021.76789.1314 | ||||
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| Authors | ||||
Mahmoud Hodeib1; Alzhraa Fahmy  2; Gamal Taha1; Mostafa Sheemy3; Manar Ali4
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| 1Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Egypt | ||||
| 2Department of Tropical Medicine and Infectious Diseases, Faculty of Medicine, Beni-Suef University, Egypt | ||||
| 3Department of Medical Microbiology and Immunology, Faculty of Medicine, Beni-Suef University, Egypt | ||||
| 4Department of Pediatrics, Beni-Suef General Hospital, Egypt | ||||
| Abstract | ||||
| Background: Hepatitis C virus [HCV] infection is a global health problem. Children with certain risk factors are at high risk of infection. Objective: The present study aimed to evaluate the prevalence of HCV among high-risk Egyptian children. Methods: The study included 1357 children aged 3-15 years with risk factors of HCV including receiving blood products, hemodialysis, previous surgical intervention, insulin therapy and positive family history. They were subjected to careful history taking, thorough clinical examination and routine laboratory investigations. All children were tested for HCV antibodies using commercial 4th generation enzyme-linked immunosorbent assay [ELISA] kits. Those with positive results were further assessed using polymerase chain reaction [PCR]. Results: Among the studied patients, there were 89 children [6.6 %] with positive HCV Ab and 73 children [5.4 %] with positive PCR test for HCV. Using multivariate logistic regression, significant predictors of HCV infection in the studied children were blood transfusion [OR: 1.23, CI: 0.019-13.4], Intravenous [IV] injection [OR: 10.962, CI: 1.937-62.026] and previous operation [OR: 3.12, CI: 1.046-31.6]. Conclusion: HCV infection is highly prevalent among high-risk children. Blood transfusion, IV injection and exposure to surgery are independent risk factors for infection in this population. | ||||
| Keywords | ||||
| Hepatitis C infection; Perinatal transmission; Hepatitis screening | ||||
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