Insulin Resistance in Chronic Kidney Disease: Is There a Distinct Role of Vitamin D? | ||||
| Suez Canal University Medical Journal | ||||
| Article 5, Volume 24, Issue 2, October 2021, Page 128-134 PDF (385.37 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/scumj.2021.192460 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Heba A Attea  1; Alaa El Din S Abd El Hamid2; Mohammed M Keshawy1; Mohamed S Khedr1
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| 1Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt | ||||
| 2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt | ||||
| Abstract | ||||
| Background: Chronic kidney disease (CKD) is associated with significant morbidity and mortality. Many factors including inflammation, oxidative stress, and vitamin D deficiency contribute to insulin resistance (IR). Vitamin D requires attention because of the kidney’s involvement in vitamin D metabolism, the high prevalence of vitamin D deficiency in CKD, and the effect of vitamin D that may cover multiple factors contributing to IR in CKD, as inflammation. Aim: To Identify the role of vitamin D deficiency in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients. Patients and Methods: The study was performed as a cross-sectional study including 84 patients with T2DM admitted in Suez Canal University Hospitals. Results: In diabetics with normal kidney function 64.3% of patients had sufficient level of vitamin D, while 14.3% of patients had vitamin D deficiency. In diabetics with late nephropathy 46.4% of patients had vitamin D deficiency with significant relationship between the progress of DN and vitamin D level (p value ≤ 0.05). Conclusion:vitamin D deficiency is strongly associated with DN. | ||||
| Keywords | ||||
| Chronic kidney disease; insulin resistance; vitamin D | ||||
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