HEREDITARY THROMBOPHILIA IN RECURRENT IVF FAILURE | ||||
| Ain Shams Medical Journal | ||||
| Article 7, Volume 72, Issue 2, June 2021, Page 301-306 PDF (855.85 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2021.192522 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Ezzat El Sobky1; Shaimaa Gad Ragheb1; Gina Mazhar Deif2 | ||||
| 1Medical genetic Department Faculty of Medicine - Ain Shams University, Egypt. | ||||
| 2Sunrise Fertility Center -IVF Laboratory Department | ||||
| Abstract | ||||
| Background: The predominant part of IVF cycles results in embryo transfer, but only about one third of all cycles reach clinically achieved pregnancy. This is evidence that most embryos failed in an early stage of pregnancy achievement. Recurrent implantation failure after IVF procedures emphasize the clinical importance of this crucial step in assisted reproductive technology. Repeated unsuccessful IVF attempts force efforts to investigate the firm mechanism of the implantation and to find approach to increase pregnancy outcome success. Plenty of factors have been recognized to affect either success, or failure rate of IVF embryo transfer. Maternal side factors include age, parity, hormonal levels before stimulation, antral follicles count, endometrial thickness and quality of transformed endometrium. Other factors, having functions in coagulation and fibrinolysis cascades, were found to be connected with the transformation processes in the endometrium during the implantation. Aim of work: The aim from this study is to evaluate the relation between hereditary thrombophilia and recurrent IVF failure. This will be done by comparing the prevalence of thrombophilia factors mutation in patients with repeated IVF failure and in normal population. Methods: Thirty patients with recurrent IVF failure underwent genetic testing of thrombophilia markers by PCR: Factor II prothrombin mutation, Factor V leiden mutation (FVL), and Methylene tetrahydrofolate reductase (MTHFR) mutation. Results: 13.3% were tested positive for factor V mutation G1619A, 56.7% were positive for MTHFR c667t mutation. While in healthy normal Mediterranean population the percentage of mutation were 3.7% for FVL mutation and 11.1% for MTHFR mutation. Conclusion: hereditary thrombophilia may be considered as a factor in recurrent IVF failure, proper management is to be considered. | ||||
| Keywords | ||||
| Recurrent IVF failure; hereditary thrombophilia; factor V mutation; MTHFR mutation; factor II prothrombin mutation | ||||
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