Comparative study between the effect of aspartame and stevia on the Purkinje cells of the cerebellar cortex of albino rats. (electron microscopic study)
bassit, A., Khalaf, A., Abdelall, A., Ali, H., Ismael, Z. (2021). Comparative study between the effect of aspartame and stevia on the Purkinje cells of the cerebellar cortex of albino rats. (electron microscopic study). EKB Journal Management System, 25(2), 93-99. doi: 10.21608/smj.2021.72094.1244
asmaa sabry bassit; Asmaa Mohammed Khalaf; Alshimaa Hafez Abdelall; Hasnaa Ahmed Ali; Zahra Mohamed Ismael. "Comparative study between the effect of aspartame and stevia on the Purkinje cells of the cerebellar cortex of albino rats. (electron microscopic study)". EKB Journal Management System, 25, 2, 2021, 93-99. doi: 10.21608/smj.2021.72094.1244
bassit, A., Khalaf, A., Abdelall, A., Ali, H., Ismael, Z. (2021). 'Comparative study between the effect of aspartame and stevia on the Purkinje cells of the cerebellar cortex of albino rats. (electron microscopic study)', EKB Journal Management System, 25(2), pp. 93-99. doi: 10.21608/smj.2021.72094.1244
bassit, A., Khalaf, A., Abdelall, A., Ali, H., Ismael, Z. Comparative study between the effect of aspartame and stevia on the Purkinje cells of the cerebellar cortex of albino rats. (electron microscopic study). EKB Journal Management System, 2021; 25(2): 93-99. doi: 10.21608/smj.2021.72094.1244

Comparative study between the effect of aspartame and stevia on the Purkinje cells of the cerebellar cortex of albino rats. (electron microscopic study)

Sohag Medical Journal
Article 12, Volume 25, Issue 2, April 2021, Page 93-99  XML PDF (728.3 K)
Document Type: Original Article
DOI: 10.21608/smj.2021.72094.1244
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Authors
asmaa sabry bassit email 1; Asmaa Mohammed Khalaf2; Alshimaa Hafez Abdelall3; Hasnaa Ahmed Ali4; Zahra Mohamed Ismael5
1anatomy department ,faculty of medicine sohage university,sohage
2forensic medicine and clinical toxicology, faculty of medicine, sohag university
3biochemistry department ,faculty of medicine sohage university,sohage
4department of a forensic medicine and clinical toxicology, faculty of medicine , sohag university
5Anatomy department faculty of medicin sohag university sohag egypt
Abstract
Abstract:
Introduction: use of sweetener natural or artificial is widely used and appeared to harm the structure of the cerebellar cortex
Aim of the work: comparison between the effect of aspartame and stevia on the Purkinje cells of the cerebellar cortex of albino rats.
Material and methods: A total of 30 adult male albino rats were used The animals were divided into Group I (Control): received distilled water, Group II (ASP treated): which received aspartame (ASP), which is given at a daily dose 250 mg/kg dissolved in distilled water for 4 weeks.
Group III (stevia treated): This received Stevia at a daily dose of 250mg/kg given orally by intragastric tube for 4 weeks. The rats' offspring from each of the groups were randomly selected, sacrificed then their skulls were
opened and their cerebellar tissues were taken for transmission electron microscope study.
Result: aspartame affected the Purkinje cells where it becomes a shrunken loss of its piriform appearance also in the stevia-treated group, the Purkinje cells lost their piriform shape with ill define cytoplasm and nuclei while Some Purkinje cells appeared normal.Conclousion: Stevioside and aspartame appeared to have a harmful effect on the structure of the purkinji cells of cerebellar cortex.
Keywords
Key word: cerebellum; purkinje; aspartame; stevia
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