ASSESSMENT OF VITAMIN D IN COLONIC DISEASES (INFLAMMATORY BOWEL DISEASES AND IRRITABLE BOWEL SYNDROME)
Sallam, H., Ghaly, S., Elsherbiny, A., Radwan, H., Eid, Y., Dawod, A. (2021). ASSESSMENT OF VITAMIN D IN COLONIC DISEASES (INFLAMMATORY BOWEL DISEASES AND IRRITABLE BOWEL SYNDROME). EKB Journal Management System, 72(2), 381-393. doi: 10.21608/asmj.2021.192585
Hebatallah Ashraf Sallam; Sameh Mohamed Ghaly; Ashraf Elsherbiny Abdel Hady Elsherbiny; Hesham Hamdy Radwan; Yasser Omar Eid; Ayman Gamil Dawod. "ASSESSMENT OF VITAMIN D IN COLONIC DISEASES (INFLAMMATORY BOWEL DISEASES AND IRRITABLE BOWEL SYNDROME)". EKB Journal Management System, 72, 2, 2021, 381-393. doi: 10.21608/asmj.2021.192585
Sallam, H., Ghaly, S., Elsherbiny, A., Radwan, H., Eid, Y., Dawod, A. (2021). 'ASSESSMENT OF VITAMIN D IN COLONIC DISEASES (INFLAMMATORY BOWEL DISEASES AND IRRITABLE BOWEL SYNDROME)', EKB Journal Management System, 72(2), pp. 381-393. doi: 10.21608/asmj.2021.192585
Sallam, H., Ghaly, S., Elsherbiny, A., Radwan, H., Eid, Y., Dawod, A. ASSESSMENT OF VITAMIN D IN COLONIC DISEASES (INFLAMMATORY BOWEL DISEASES AND IRRITABLE BOWEL SYNDROME). EKB Journal Management System, 2021; 72(2): 381-393. doi: 10.21608/asmj.2021.192585

ASSESSMENT OF VITAMIN D IN COLONIC DISEASES (INFLAMMATORY BOWEL DISEASES AND IRRITABLE BOWEL SYNDROME)

Ain Shams Medical Journal
Article 15, Volume 72, Issue 2, June 2021, Page 381-393  XML PDF (968.44 K)
Document Type: Original Article
DOI: 10.21608/asmj.2021.192585
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Authors
Hebatallah Ashraf Sallam1; Sameh Mohamed Ghaly2; Ashraf Elsherbiny Abdel Hady Elsherbiny1; Hesham Hamdy Radwan2; Yasser Omar Eid2; Ayman Gamil Dawod2
1Department of Internal Medicine , National Research Center, Cairo, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Background: Vitamin D is a steroid hormone that is produced as a result of skin exposure to the sunlight. Vitamin D is essential to different organs and systems in the body as the bones, intestines, immune system, pancreas, brain, and control of cell cycle.
Aim of the work: to assess the clinical relevance of vitamin D in colonic diseases (IBS and IBD) to know if there is a prevalence of vitamin D deficiency in these colonic diseases.
Patients and Methods: This study was performed on 90 Egyptian patients who were classified into 3 groups; where Group 1 included 30 patients who have irritable bowel syndrome (IBS), Group 2 30 patients who have inflammatory bowel disease (IBD) whether Ulcerative Colitis (UC) or Crohn's Disease (CD) and Group 3 30 healthy personnel taken as Control group.
Results: Regarding different vitamin D levels in the studied groups. In the control group, (20%) had deficient vitamin D level (< 20 ng/ml), (30%) had insufficient vitamin D level (20 – 30 ng/ml), (50%) had optimal vitamin D level (>30 ng/ml). In IBS group, (60%) had deficient vitamin D level, (26.7%) had insufficient vitamin D level, (13.3%) had optimal vitamin D level. In the UC group, (66.7%) had deficient vitamin D level, (16.7%) had insufficient vitamin D level, (16.7%) had optimal vitamin D level. In CD group, (50%) had deficient vitamin D level, (33.3%) had insufficient vitamin D level, (16.7%) had optimal vitamin D level.
Conclusion: The role of vitamin D deficiency in the pathogenesis of many chronic illnesses has raised the attention recently. Our study revealed that 25-OH-D3 deficiency is found more frequently among UC, CD and IBS patients than normal healthy controls. Thus, vitamin D prescription in these patients may help in improving these colonic diseases.
Keywords
Inflammatory bowel diseases; irritable bowel syndrome
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