Cytotoxic and Antileishmanial Activities of the Red Sea Soft Coral Sarcophyton glaucum Extract and Some of Its Isolates | ||||
Records of Pharmaceutical and Biomedical Sciences | ||||
Article 12, Volume 5, Pharmacognosy-Microbiology - Serial Number 2, January 2021, Page 115-120 PDF (293.87 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/rpbs.2021.90767.1111 | ||||
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Authors | ||||
Mayada Mohamed El-Ayouty1; Reda Foaad Abdelhameed2; Eman Sanad Habib3; Hashim Hassanean4; Safwat Ahmed 4 | ||||
1Department of Pharmacognosy, Faculty of Pharmacy, Sinai University, El-Arish, Egypt | ||||
2Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. | ||||
3Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522, Ismailia, Egypt | ||||
4Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. | ||||
Abstract | ||||
Truthfully, natural products have been the principal productive source of advancing new drugs. The broad aim of this work was to conduct a phytochemical and biological study of the Red Sea soft coral Sarcophyton glaucum, Family: Alcyoniidae collected from Red Sea at the Egyptian coasts. The phytochemical investigation from the soft coral S. glaucum led to the isolation of ten compounds including: palmitic acid (1), stearic acid (2), (24S)-24-methyl cholesterol (3), batyl alcohol (4), heptadecanoic acid pentadecyl ester (5), sarcophine (6), (+)-7α, 8β-dihydroxydeepoxysarcophine (7), uracil (8), thymine (9) and a ceramide (10). As cancer is one of the most hazardous factors threatening the human life, in this study the potential in-vitro cytotoxicity of the soft coral S. glaucum extract and three marine isolates were measured against HepG2 and MCF7 using Sulphorhodamine-B (SRB) assay and all of the tested samples showed a good cytotoxic activities against both hepatic and breast cancer. The extract of S. glaucum was tested also against the protozoan parasite Leishmania donovani, using pentamidine and amphotericin B as controls and showed antileishmanial activity. | ||||
Keywords | ||||
Sarcophyton glaucum; cytotoxic activity; antileishmanial activity | ||||
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